Prognostic value of consolidation-to-tumor ratio on computed tomography in NSCLC: a meta-analysis
Abstract Background Although several studies have confirmed the prognostic value of the consolidation to tumor ratio (CTR) in non-small cell lung cancer (NSCLC), there still remains controversial about it. Methods We systematically searched the PubMed, Embase, and Web of Science databases from incep...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-023-03081-y |
| _version_ | 1797795660106301440 |
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| author | Yongming Wu Wenpeng Song Denian Wang Junke Chang Yan Wang Jie Tian Sicheng Zhou Yingxian Dong Jing Zhou Jue Li Ziyi Zhao Guowei Che |
| author_facet | Yongming Wu Wenpeng Song Denian Wang Junke Chang Yan Wang Jie Tian Sicheng Zhou Yingxian Dong Jing Zhou Jue Li Ziyi Zhao Guowei Che |
| author_sort | Yongming Wu |
| collection | DOAJ |
| description | Abstract Background Although several studies have confirmed the prognostic value of the consolidation to tumor ratio (CTR) in non-small cell lung cancer (NSCLC), there still remains controversial about it. Methods We systematically searched the PubMed, Embase, and Web of Science databases from inception to April, 2022 for eligible studies that reported the correlation between CTR and prognosis in NSCLC. Hazard ratios (HRs) with 95% confidence intervals (95% CIs) were extracted and pooled to assess the overall effects. Heterogeneity was estimated by I 2 statistics. Subgroup analysis based on the cut-off value of CTR, country, source of HR and histology type was conducted to detect the sources of heterogeneity. Statistical analyses were performed using STATA version 12.0. Results A total of 29 studies published between 2001 and 2022 with 10,347 patients were enrolled. The pooled results demonstrated that elevated CTR was associated with poorer overall survival (HR = 1.88, 95% CI 1.42–2.50, P < 0.01) and disease-free survival (DFS)/recurrence-free survival (RFS)/progression-free survival (PFS) (HR = 1.42, 95% CI 1.27–1.59, P < 0.01) in NSCLC. According to subgroup analysis by the cut-off value of CTR and histology type, both lung adenocarcinoma and NSCLC patients who had a higher CTR showed worse survival. Subgroup analysis stratified by country revealed that CTR was a prognostic factor for OS and DFS/RFS/PFS in Chinese, Japanese, and Turkish patients. Conclusions In NSCLC patients with high CTR, the prognosis was worse than that with low CTR, indicating that CTR may be a prognostic factor. |
| first_indexed | 2024-03-13T03:21:21Z |
| format | Article |
| id | doaj.art-99ad5e9374ea41189cc182e52d8f76eb |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-03-13T03:21:21Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-99ad5e9374ea41189cc182e52d8f76eb2023-06-25T11:19:08ZengBMCWorld Journal of Surgical Oncology1477-78192023-06-0121111210.1186/s12957-023-03081-yPrognostic value of consolidation-to-tumor ratio on computed tomography in NSCLC: a meta-analysisYongming Wu0Wenpeng Song1Denian Wang2Junke Chang3Yan Wang4Jie Tian5Sicheng Zhou6Yingxian Dong7Jing Zhou8Jue Li9Ziyi Zhao10Guowei Che11Department of Thoracic Surgery, West China Hospital, Sichuan UniversityDepartment of Thoracic Surgery, West China Hospital, Sichuan UniversityPrecision Medicine Center, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan UniversityDepartment of Thoracic Surgery, West China Hospital, Sichuan UniversityDepartment of Thoracic Surgery, West China Hospital, Sichuan UniversityDepartment of Thoracic Surgery, West China Hospital, Sichuan UniversityDepartment of Thoracic Surgery, West China Hospital, Sichuan UniversityDepartment of Thoracic Surgery, West China Hospital, Sichuan UniversityDepartment of Respiratory and Critical Care Medicine, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan UniversityDepartment of Thoracic Surgery, West China Hospital, Sichuan UniversityDepartment of Thoracic Surgery, West China Hospital, Sichuan UniversityDepartment of Thoracic Surgery, West China Hospital, Sichuan UniversityAbstract Background Although several studies have confirmed the prognostic value of the consolidation to tumor ratio (CTR) in non-small cell lung cancer (NSCLC), there still remains controversial about it. Methods We systematically searched the PubMed, Embase, and Web of Science databases from inception to April, 2022 for eligible studies that reported the correlation between CTR and prognosis in NSCLC. Hazard ratios (HRs) with 95% confidence intervals (95% CIs) were extracted and pooled to assess the overall effects. Heterogeneity was estimated by I 2 statistics. Subgroup analysis based on the cut-off value of CTR, country, source of HR and histology type was conducted to detect the sources of heterogeneity. Statistical analyses were performed using STATA version 12.0. Results A total of 29 studies published between 2001 and 2022 with 10,347 patients were enrolled. The pooled results demonstrated that elevated CTR was associated with poorer overall survival (HR = 1.88, 95% CI 1.42–2.50, P < 0.01) and disease-free survival (DFS)/recurrence-free survival (RFS)/progression-free survival (PFS) (HR = 1.42, 95% CI 1.27–1.59, P < 0.01) in NSCLC. According to subgroup analysis by the cut-off value of CTR and histology type, both lung adenocarcinoma and NSCLC patients who had a higher CTR showed worse survival. Subgroup analysis stratified by country revealed that CTR was a prognostic factor for OS and DFS/RFS/PFS in Chinese, Japanese, and Turkish patients. Conclusions In NSCLC patients with high CTR, the prognosis was worse than that with low CTR, indicating that CTR may be a prognostic factor.https://doi.org/10.1186/s12957-023-03081-yNon-small cell lung cancerConsolidation to tumor ratioPrognosticMeta-analysis |
| spellingShingle | Yongming Wu Wenpeng Song Denian Wang Junke Chang Yan Wang Jie Tian Sicheng Zhou Yingxian Dong Jing Zhou Jue Li Ziyi Zhao Guowei Che Prognostic value of consolidation-to-tumor ratio on computed tomography in NSCLC: a meta-analysis World Journal of Surgical Oncology Non-small cell lung cancer Consolidation to tumor ratio Prognostic Meta-analysis |
| title | Prognostic value of consolidation-to-tumor ratio on computed tomography in NSCLC: a meta-analysis |
| title_full | Prognostic value of consolidation-to-tumor ratio on computed tomography in NSCLC: a meta-analysis |
| title_fullStr | Prognostic value of consolidation-to-tumor ratio on computed tomography in NSCLC: a meta-analysis |
| title_full_unstemmed | Prognostic value of consolidation-to-tumor ratio on computed tomography in NSCLC: a meta-analysis |
| title_short | Prognostic value of consolidation-to-tumor ratio on computed tomography in NSCLC: a meta-analysis |
| title_sort | prognostic value of consolidation to tumor ratio on computed tomography in nsclc a meta analysis |
| topic | Non-small cell lung cancer Consolidation to tumor ratio Prognostic Meta-analysis |
| url | https://doi.org/10.1186/s12957-023-03081-y |
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