Relationship between serum iron and blood eosinophil counts in asthmatic adults: data from NHANES 2011-2018
BackgroundSo far, quite a few studies have revealed that systemic iron levels are related to asthmatic inflammatory reactions. And most studies have focused on the correlation between systemic iron levels and asthma, with inconsistent findings. Yet, few studies have investigated the connection betwe...
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1201160/full |
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| author | Jun Wen Changfen Wang Jing Xia Mohan Giri Shuliang Guo |
| author_facet | Jun Wen Changfen Wang Jing Xia Mohan Giri Shuliang Guo |
| author_sort | Jun Wen |
| collection | DOAJ |
| description | BackgroundSo far, quite a few studies have revealed that systemic iron levels are related to asthmatic inflammatory reactions. And most studies have focused on the correlation between systemic iron levels and asthma, with inconsistent findings. Yet, few studies have investigated the connection between serum iron and blood eosinophil counts. Hence, we have explored the connection between serum iron and blood eosinophil counts in asthmatics by utilizing data from NHANES.MethodsA total of 2549 individuals were included in our study after screening NHANES participants from 2011 to 2018. The linear regression model and XGBoost model were used to discuss the potential connection. Linear or nonlinear association was further confirmed by the generalized additive model and the piecewise linear regression model. And we also performed stratified analyses to figure out specific populations.ResultsIn the multivariable linear regression models, we discovered that serum iron levels were inversely related to blood eosinophil counts in asthmatic adults. Simultaneously, we found that for every unit increase in serum iron (umol/L), blood eosinophil counts reduced by 1.41/uL in model 3, which adjusted for all variables excluding the analyzed variables. Furthermore, the XGBoost model of machine learning was applied to assess the relative importance of chosen variables, and it was determined that vitamin C intake, age, vitamin B12 intake, iron intake, and serum iron were the five most important variables on blood eosinophil counts. And the generalized additive model and piecewise linear regression model further verify this linear and inverse association.ConclusionOur investigation discovered that the linear and inverse association of serum iron with blood eosinophil counts in asthmatic adults, indicating that serum iron might be related to changes in the immunological state of asthmatics. Our work offers some new thoughts for next research on asthma management and therapy. Ultimately, we hope that more individuals become aware of the role of iron in the onset, development, and treatment of asthma. |
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| language | English |
| last_indexed | 2024-03-12T02:39:30Z |
| publishDate | 2023-09-01 |
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| spelling | doaj.art-99aecab9eb6e4fe2ad9f299b8a57dab22023-09-04T08:07:36ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-09-011410.3389/fimmu.2023.12011601201160Relationship between serum iron and blood eosinophil counts in asthmatic adults: data from NHANES 2011-2018Jun Wen0Changfen Wang1Jing Xia2Mohan Giri3Shuliang Guo4Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, ChinaDepartment of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, ChinaDepartment of Respiratory and Critical Care Medicine, The Third Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, ChinaDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, ChinaDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, ChinaBackgroundSo far, quite a few studies have revealed that systemic iron levels are related to asthmatic inflammatory reactions. And most studies have focused on the correlation between systemic iron levels and asthma, with inconsistent findings. Yet, few studies have investigated the connection between serum iron and blood eosinophil counts. Hence, we have explored the connection between serum iron and blood eosinophil counts in asthmatics by utilizing data from NHANES.MethodsA total of 2549 individuals were included in our study after screening NHANES participants from 2011 to 2018. The linear regression model and XGBoost model were used to discuss the potential connection. Linear or nonlinear association was further confirmed by the generalized additive model and the piecewise linear regression model. And we also performed stratified analyses to figure out specific populations.ResultsIn the multivariable linear regression models, we discovered that serum iron levels were inversely related to blood eosinophil counts in asthmatic adults. Simultaneously, we found that for every unit increase in serum iron (umol/L), blood eosinophil counts reduced by 1.41/uL in model 3, which adjusted for all variables excluding the analyzed variables. Furthermore, the XGBoost model of machine learning was applied to assess the relative importance of chosen variables, and it was determined that vitamin C intake, age, vitamin B12 intake, iron intake, and serum iron were the five most important variables on blood eosinophil counts. And the generalized additive model and piecewise linear regression model further verify this linear and inverse association.ConclusionOur investigation discovered that the linear and inverse association of serum iron with blood eosinophil counts in asthmatic adults, indicating that serum iron might be related to changes in the immunological state of asthmatics. Our work offers some new thoughts for next research on asthma management and therapy. Ultimately, we hope that more individuals become aware of the role of iron in the onset, development, and treatment of asthma.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1201160/fullserum ironeosinophilasthmaNational Health And Nutrition Examination Survey (NHANES)XGBoostmachine learning |
| spellingShingle | Jun Wen Changfen Wang Jing Xia Mohan Giri Shuliang Guo Relationship between serum iron and blood eosinophil counts in asthmatic adults: data from NHANES 2011-2018 Frontiers in Immunology serum iron eosinophil asthma National Health And Nutrition Examination Survey (NHANES) XGBoost machine learning |
| title | Relationship between serum iron and blood eosinophil counts in asthmatic adults: data from NHANES 2011-2018 |
| title_full | Relationship between serum iron and blood eosinophil counts in asthmatic adults: data from NHANES 2011-2018 |
| title_fullStr | Relationship between serum iron and blood eosinophil counts in asthmatic adults: data from NHANES 2011-2018 |
| title_full_unstemmed | Relationship between serum iron and blood eosinophil counts in asthmatic adults: data from NHANES 2011-2018 |
| title_short | Relationship between serum iron and blood eosinophil counts in asthmatic adults: data from NHANES 2011-2018 |
| title_sort | relationship between serum iron and blood eosinophil counts in asthmatic adults data from nhanes 2011 2018 |
| topic | serum iron eosinophil asthma National Health And Nutrition Examination Survey (NHANES) XGBoost machine learning |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1201160/full |
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