LPS-Inducible lncRNA TMC3-AS1 Negatively Regulates the Expression of IL-10

LPS-Inducible lncRNA TMC3-AS1 Negatively Regulates the Expression of IL-10

Long non-coding RNAs are essential regulators of the inflammatory response, especially for transcriptional regulation of inflammatory genes. It has been reported that the expression of transmembrane channel-like 3 (TMC3)–AS1 is increased following lipopolysaccharide stimulation. However, the potenti...

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Bibliographic Details
Main Authors: Mengling Ye, Minghong Xie, Jie Zhu, Chen Wang, Rui Zhou, Xiaoqing Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
NF-κB
TMC3-AS1
IL-10
innate immunity
TLR4
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01418/full
Description
Summary:Long non-coding RNAs are essential regulators of the inflammatory response, especially for transcriptional regulation of inflammatory genes. It has been reported that the expression of transmembrane channel-like 3 (TMC3)–AS1 is increased following lipopolysaccharide stimulation. However, the potential function of TMC3-AS1 in immunity is largely unknown. Herein, we report a specific role for TMC3-AS1 in the regulation of inflammatory gene expression. TMC3-AS1 negatively regulates the expression of interleukin 10 (IL-10) in macrophage and intestinal epithelial cell lines. Mechanistically, TMC3-AS1 may interact with p65 in the nucleus, preventing p65 from binding to the κB consensus site within IL-10 promoter. These findings suggest that TMC3-AS1 may function as an important regulator in the innate immune response.
ISSN:1664-3224

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