Marine Sources of DHA-Rich Phospholipids with Anti-Alzheimer Effect
Alzheimer’s disease (AD) is a complex and progressive disease, which affects millions of people around the world. Despite the many efforts over the years to find efficient therapeutics, there is no cure yet. Nonetheless, many compounds have been proven to decrease Alzheimer’s symptoms. After a short...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/20/11/662 |
| _version_ | 1797467530347937792 |
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| author | Inês Ferreira Amélia P. Rauter Narcisa M. Bandarra |
| author_facet | Inês Ferreira Amélia P. Rauter Narcisa M. Bandarra |
| author_sort | Inês Ferreira |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a complex and progressive disease, which affects millions of people around the world. Despite the many efforts over the years to find efficient therapeutics, there is no cure yet. Nonetheless, many compounds have been proven to decrease Alzheimer’s symptoms. After a short overview of the hypotheses considered in AD drug development and the drugs approved for AD treatment, which lead to symptom release, we focus on the valorization of natural marine sources that decrease AD symptoms, particularly on docosahexaenoic acid (DHA), an important component in membrane phospholipids and the most abundant n−3 polyunsaturated fatty acids (PUFA) found in gray matter of the brain and in retina and on the DHA-containing phospholipids (DHA-PLs) present in marine sources, namely fish, krill, mollusks and in fisheries and aquaculture by-products. DHA-PLs’ bioactivities are presented, namely their properties in anti-neurodegeneration, neuroinflammation, as anticancer agents, as well as their benefits to obesity and visual problems. Fisheries and aquaculture by-products are also highlighted as they have a high content of DHA and DHA-rich phospholipids, can be extracted by green methodologies and should be considered in a circular economy for a healthy sustainable future. |
| first_indexed | 2024-03-09T18:54:58Z |
| format | Article |
| id | doaj.art-99b29f411cea448c81e73f161262e006 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-09T18:54:58Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-99b29f411cea448c81e73f161262e0062023-11-24T05:34:04ZengMDPI AGMarine Drugs1660-33972022-10-01201166210.3390/md20110662Marine Sources of DHA-Rich Phospholipids with Anti-Alzheimer EffectInês Ferreira0Amélia P. Rauter1Narcisa M. Bandarra2Centro de Química Estrutural, Institute of Molecular Sciences, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, PortugalCentro de Química Estrutural, Institute of Molecular Sciences, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, PortugalDivision of Aquaculture, Upgrading and Bioprospecting, Portuguese Institute of the Sea and Atmosphere, 1495-165 Lisboa, PortugalAlzheimer’s disease (AD) is a complex and progressive disease, which affects millions of people around the world. Despite the many efforts over the years to find efficient therapeutics, there is no cure yet. Nonetheless, many compounds have been proven to decrease Alzheimer’s symptoms. After a short overview of the hypotheses considered in AD drug development and the drugs approved for AD treatment, which lead to symptom release, we focus on the valorization of natural marine sources that decrease AD symptoms, particularly on docosahexaenoic acid (DHA), an important component in membrane phospholipids and the most abundant n−3 polyunsaturated fatty acids (PUFA) found in gray matter of the brain and in retina and on the DHA-containing phospholipids (DHA-PLs) present in marine sources, namely fish, krill, mollusks and in fisheries and aquaculture by-products. DHA-PLs’ bioactivities are presented, namely their properties in anti-neurodegeneration, neuroinflammation, as anticancer agents, as well as their benefits to obesity and visual problems. Fisheries and aquaculture by-products are also highlighted as they have a high content of DHA and DHA-rich phospholipids, can be extracted by green methodologies and should be considered in a circular economy for a healthy sustainable future.https://www.mdpi.com/1660-3397/20/11/662Alzheimer’s diseasephospholipidsdocosahexaenoic acidmarine sources |
| spellingShingle | Inês Ferreira Amélia P. Rauter Narcisa M. Bandarra Marine Sources of DHA-Rich Phospholipids with Anti-Alzheimer Effect Marine Drugs Alzheimer’s disease phospholipids docosahexaenoic acid marine sources |
| title | Marine Sources of DHA-Rich Phospholipids with Anti-Alzheimer Effect |
| title_full | Marine Sources of DHA-Rich Phospholipids with Anti-Alzheimer Effect |
| title_fullStr | Marine Sources of DHA-Rich Phospholipids with Anti-Alzheimer Effect |
| title_full_unstemmed | Marine Sources of DHA-Rich Phospholipids with Anti-Alzheimer Effect |
| title_short | Marine Sources of DHA-Rich Phospholipids with Anti-Alzheimer Effect |
| title_sort | marine sources of dha rich phospholipids with anti alzheimer effect |
| topic | Alzheimer’s disease phospholipids docosahexaenoic acid marine sources |
| url | https://www.mdpi.com/1660-3397/20/11/662 |
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