Repeated Dose of Contrast Media and the Risk of Contrast-Induced Acute Kidney Injury in a Broad Population of Patients Hospitalized in Cardiology Department
Contrast-induced acute kidney injury (CI-AKI) can lead to the development of chronic kidney disease (CKD) and impaired in-hospital and long-term outcomes among cardiac patients. The aim of this study was to evaluate the impact of repeated contrast media (CM) administration during a single hospitaliz...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/12/6/2166 |
| _version_ | 1797611029828468736 |
|---|---|
| author | Małgorzata Cichoń Maciej T. Wybraniec Oliwia Okoń Marek Zielonka Sofija Antoniuk Tomasz Szatan Katarzyna Mizia-Stec |
| author_facet | Małgorzata Cichoń Maciej T. Wybraniec Oliwia Okoń Marek Zielonka Sofija Antoniuk Tomasz Szatan Katarzyna Mizia-Stec |
| author_sort | Małgorzata Cichoń |
| collection | DOAJ |
| description | Contrast-induced acute kidney injury (CI-AKI) can lead to the development of chronic kidney disease (CKD) and impaired in-hospital and long-term outcomes among cardiac patients. The aim of this study was to evaluate the impact of repeated contrast media (CM) administration during a single hospitalization on the rate of CI-AKI. The study group (<i>n</i> = 138) comprised patients with different diagnoses who received CM more than once during hospitalization, while the control group (<i>n</i> = 153) involved CAD patients subject to a single CM dose. Following propensity score matching (PSM), both groups of <i>n</i> = 84 were evenly matched in terms of major baseline variables. CI-AKI was defined by an absolute increase in SCr ≥ 0.3 mg/dL or >50% relative to the baseline value within 48–72 h from the last CM dose. Patients in the study group were older, had a higher prevalence of diabetes and CKD, received a higher total volume of CM, had a lower left ventricular ejection fraction, lower prevalence of multivessel coronary artery disease (MV-CAD), and a trend towards a lower prevalence of arterial hypertension and smoking. SCr did not differ between the study and control groups at 72 h after the CM use. CI-AKI occurred in 18 patients in the study (13.0%) and in 18 patients (11.8%) in the control group (<i>p</i> = 0.741). The rate of CI-AKI was also comparable following the PSM (13.1% vs. 13.1%, <i>p</i> = 1.0). Logistic regression analysis revealed that CKD, diabetes mellitus, MV-CAD, age, and non-steroidal anti-inflammatory drugs use, but not repeated CM use, were independent predictors of CI-AKI. |
| first_indexed | 2024-03-11T06:23:14Z |
| format | Article |
| id | doaj.art-99b3231c52f04f9ba24b57795bf48b89 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T06:23:14Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-99b3231c52f04f9ba24b57795bf48b892023-11-17T11:48:59ZengMDPI AGJournal of Clinical Medicine2077-03832023-03-01126216610.3390/jcm12062166Repeated Dose of Contrast Media and the Risk of Contrast-Induced Acute Kidney Injury in a Broad Population of Patients Hospitalized in Cardiology DepartmentMałgorzata Cichoń0Maciej T. Wybraniec1Oliwia Okoń2Marek Zielonka3Sofija Antoniuk4Tomasz Szatan5Katarzyna Mizia-Stec6First Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, 40-635 Katowice, PolandFirst Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, 40-635 Katowice, PolandFirst Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, 40-635 Katowice, PolandFirst Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, 40-635 Katowice, PolandFirst Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, 40-635 Katowice, PolandDepartment of Cardiology in Cieszyn, Upper-Silesian Medical Center, 40635 Katowice, PolandFirst Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, 40-635 Katowice, PolandContrast-induced acute kidney injury (CI-AKI) can lead to the development of chronic kidney disease (CKD) and impaired in-hospital and long-term outcomes among cardiac patients. The aim of this study was to evaluate the impact of repeated contrast media (CM) administration during a single hospitalization on the rate of CI-AKI. The study group (<i>n</i> = 138) comprised patients with different diagnoses who received CM more than once during hospitalization, while the control group (<i>n</i> = 153) involved CAD patients subject to a single CM dose. Following propensity score matching (PSM), both groups of <i>n</i> = 84 were evenly matched in terms of major baseline variables. CI-AKI was defined by an absolute increase in SCr ≥ 0.3 mg/dL or >50% relative to the baseline value within 48–72 h from the last CM dose. Patients in the study group were older, had a higher prevalence of diabetes and CKD, received a higher total volume of CM, had a lower left ventricular ejection fraction, lower prevalence of multivessel coronary artery disease (MV-CAD), and a trend towards a lower prevalence of arterial hypertension and smoking. SCr did not differ between the study and control groups at 72 h after the CM use. CI-AKI occurred in 18 patients in the study (13.0%) and in 18 patients (11.8%) in the control group (<i>p</i> = 0.741). The rate of CI-AKI was also comparable following the PSM (13.1% vs. 13.1%, <i>p</i> = 1.0). Logistic regression analysis revealed that CKD, diabetes mellitus, MV-CAD, age, and non-steroidal anti-inflammatory drugs use, but not repeated CM use, were independent predictors of CI-AKI.https://www.mdpi.com/2077-0383/12/6/2166contrast-induced acute kidney injuryCI-AKIcontrast-induced nephropathyCINrepeated contrast medium |
| spellingShingle | Małgorzata Cichoń Maciej T. Wybraniec Oliwia Okoń Marek Zielonka Sofija Antoniuk Tomasz Szatan Katarzyna Mizia-Stec Repeated Dose of Contrast Media and the Risk of Contrast-Induced Acute Kidney Injury in a Broad Population of Patients Hospitalized in Cardiology Department Journal of Clinical Medicine contrast-induced acute kidney injury CI-AKI contrast-induced nephropathy CIN repeated contrast medium |
| title | Repeated Dose of Contrast Media and the Risk of Contrast-Induced Acute Kidney Injury in a Broad Population of Patients Hospitalized in Cardiology Department |
| title_full | Repeated Dose of Contrast Media and the Risk of Contrast-Induced Acute Kidney Injury in a Broad Population of Patients Hospitalized in Cardiology Department |
| title_fullStr | Repeated Dose of Contrast Media and the Risk of Contrast-Induced Acute Kidney Injury in a Broad Population of Patients Hospitalized in Cardiology Department |
| title_full_unstemmed | Repeated Dose of Contrast Media and the Risk of Contrast-Induced Acute Kidney Injury in a Broad Population of Patients Hospitalized in Cardiology Department |
| title_short | Repeated Dose of Contrast Media and the Risk of Contrast-Induced Acute Kidney Injury in a Broad Population of Patients Hospitalized in Cardiology Department |
| title_sort | repeated dose of contrast media and the risk of contrast induced acute kidney injury in a broad population of patients hospitalized in cardiology department |
| topic | contrast-induced acute kidney injury CI-AKI contrast-induced nephropathy CIN repeated contrast medium |
| url | https://www.mdpi.com/2077-0383/12/6/2166 |
| work_keys_str_mv | AT małgorzatacichon repeateddoseofcontrastmediaandtheriskofcontrastinducedacutekidneyinjuryinabroadpopulationofpatientshospitalizedincardiologydepartment AT maciejtwybraniec repeateddoseofcontrastmediaandtheriskofcontrastinducedacutekidneyinjuryinabroadpopulationofpatientshospitalizedincardiologydepartment AT oliwiaokon repeateddoseofcontrastmediaandtheriskofcontrastinducedacutekidneyinjuryinabroadpopulationofpatientshospitalizedincardiologydepartment AT marekzielonka repeateddoseofcontrastmediaandtheriskofcontrastinducedacutekidneyinjuryinabroadpopulationofpatientshospitalizedincardiologydepartment AT sofijaantoniuk repeateddoseofcontrastmediaandtheriskofcontrastinducedacutekidneyinjuryinabroadpopulationofpatientshospitalizedincardiologydepartment AT tomaszszatan repeateddoseofcontrastmediaandtheriskofcontrastinducedacutekidneyinjuryinabroadpopulationofpatientshospitalizedincardiologydepartment AT katarzynamiziastec repeateddoseofcontrastmediaandtheriskofcontrastinducedacutekidneyinjuryinabroadpopulationofpatientshospitalizedincardiologydepartment |