The Temporal and Spatial Dynamics of Cortical Emotion Processing in Different Brain Frequencies as Assessed Using the Cluster-Based Permutation Test: An MEG Study
The processing of emotions in the human brain is an extremely complex process that extends across a large number of brain areas and various temporal processing steps. In the case of magnetoencephalography (MEG) data, various frequency bands also contribute differently. Therefore, in most studies, th...
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| Format: | Article |
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MDPI AG
2020-06-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/10/6/352 |
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| author | Mina Kheirkhah Philipp Baumbach Lutz Leistritz Stefan Brodoehl Theresa Götz Ralph Huonker Otto W. Witte Carsten M. Klingner |
| author_facet | Mina Kheirkhah Philipp Baumbach Lutz Leistritz Stefan Brodoehl Theresa Götz Ralph Huonker Otto W. Witte Carsten M. Klingner |
| author_sort | Mina Kheirkhah |
| collection | DOAJ |
| description | The processing of emotions in the human brain is an extremely complex process that extends across a large number of brain areas and various temporal processing steps. In the case of magnetoencephalography (MEG) data, various frequency bands also contribute differently. Therefore, in most studies, the analysis of emotional processing has to be limited to specific sub-aspects. Here, we demonstrated that these problems can be overcome by using a nonparametric statistical test called the cluster-based permutation test (CBPT). To the best of our knowledge, our study is the first to apply the CBPT to MEG data of brain responses to emotional stimuli. For this purpose, different emotionally impacting (pleasant and unpleasant) and neutral pictures were presented to 17 healthy subjects. The CBPT was applied to the power spectra of five brain frequencies, comparing responses to emotional versus neutral stimuli over entire MEG channels and time intervals within 1500 ms post-stimulus. Our results showed significant clusters in different frequency bands, and agreed well with many previous emotion studies. However, the use of the CBPT allowed us to easily include large numbers of MEG channels, wide frequency, and long time-ranges in one study, which is a more reliable alternative to other studies that consider only specific sub-aspects. |
| first_indexed | 2024-03-10T19:20:04Z |
| format | Article |
| id | doaj.art-99b3a79480f2496fb8fcef297f7ac44a |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T19:20:04Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-99b3a79480f2496fb8fcef297f7ac44a2023-11-20T03:04:13ZengMDPI AGBrain Sciences2076-34252020-06-0110635210.3390/brainsci10060352The Temporal and Spatial Dynamics of Cortical Emotion Processing in Different Brain Frequencies as Assessed Using the Cluster-Based Permutation Test: An MEG StudyMina Kheirkhah0Philipp Baumbach1Lutz Leistritz2Stefan Brodoehl3Theresa Götz4Ralph Huonker5Otto W. Witte6Carsten M. Klingner7Biomagnetic Center, Jena University Hospital, 07747 Jena, GermanyDepartment of Anesthesiology and Intensive Care Medicine, Jena University Hospital, 07747 Jena, GermanyInstitute of Medical Statistics, Computer and Data Sciences, Jena University Hospital, 07740 Jena, GermanyBiomagnetic Center, Jena University Hospital, 07747 Jena, GermanyBiomagnetic Center, Jena University Hospital, 07747 Jena, GermanyBiomagnetic Center, Jena University Hospital, 07747 Jena, GermanyHans Berger Department of Neurology, Jena University Hospital, 07747 Jena, GermanyBiomagnetic Center, Jena University Hospital, 07747 Jena, GermanyThe processing of emotions in the human brain is an extremely complex process that extends across a large number of brain areas and various temporal processing steps. In the case of magnetoencephalography (MEG) data, various frequency bands also contribute differently. Therefore, in most studies, the analysis of emotional processing has to be limited to specific sub-aspects. Here, we demonstrated that these problems can be overcome by using a nonparametric statistical test called the cluster-based permutation test (CBPT). To the best of our knowledge, our study is the first to apply the CBPT to MEG data of brain responses to emotional stimuli. For this purpose, different emotionally impacting (pleasant and unpleasant) and neutral pictures were presented to 17 healthy subjects. The CBPT was applied to the power spectra of five brain frequencies, comparing responses to emotional versus neutral stimuli over entire MEG channels and time intervals within 1500 ms post-stimulus. Our results showed significant clusters in different frequency bands, and agreed well with many previous emotion studies. However, the use of the CBPT allowed us to easily include large numbers of MEG channels, wide frequency, and long time-ranges in one study, which is a more reliable alternative to other studies that consider only specific sub-aspects.https://www.mdpi.com/2076-3425/10/6/352alphabetacluster-based permutation testdeltaemotiongamma |
| spellingShingle | Mina Kheirkhah Philipp Baumbach Lutz Leistritz Stefan Brodoehl Theresa Götz Ralph Huonker Otto W. Witte Carsten M. Klingner The Temporal and Spatial Dynamics of Cortical Emotion Processing in Different Brain Frequencies as Assessed Using the Cluster-Based Permutation Test: An MEG Study Brain Sciences alpha beta cluster-based permutation test delta emotion gamma |
| title | The Temporal and Spatial Dynamics of Cortical Emotion Processing in Different Brain Frequencies as Assessed Using the Cluster-Based Permutation Test: An MEG Study |
| title_full | The Temporal and Spatial Dynamics of Cortical Emotion Processing in Different Brain Frequencies as Assessed Using the Cluster-Based Permutation Test: An MEG Study |
| title_fullStr | The Temporal and Spatial Dynamics of Cortical Emotion Processing in Different Brain Frequencies as Assessed Using the Cluster-Based Permutation Test: An MEG Study |
| title_full_unstemmed | The Temporal and Spatial Dynamics of Cortical Emotion Processing in Different Brain Frequencies as Assessed Using the Cluster-Based Permutation Test: An MEG Study |
| title_short | The Temporal and Spatial Dynamics of Cortical Emotion Processing in Different Brain Frequencies as Assessed Using the Cluster-Based Permutation Test: An MEG Study |
| title_sort | temporal and spatial dynamics of cortical emotion processing in different brain frequencies as assessed using the cluster based permutation test an meg study |
| topic | alpha beta cluster-based permutation test delta emotion gamma |
| url | https://www.mdpi.com/2076-3425/10/6/352 |
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