GABP is necessary for stem/progenitor cell maintenance and myeloid differentiation in human hematopoiesis and chronic myeloid leukemia

GABP is necessary for stem/progenitor cell maintenance and myeloid differentiation in human hematopoiesis and chronic myeloid leukemia

Maintenance of hematopoietic stem cells and their potential to give rise to progenitors of differentiated lymphoid and myeloid cells are accomplished by a network of regulatory processes. As a part of this network, the heteromeric transcription factor GA-binding protein (GABP) plays a crucial role i...

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Bibliographic Details
Main Authors: Georgi Manukjan, Tim Ripperger, Letizia Venturini, Michael Stadler, Gudrun Göhring, Axel Schambach, Brigitte Schlegelberger, Doris Steinemann
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Stem Cell Research
Subjects:
GABP
Transcription factor
Hematopoietic stem cell
Leukemic stem cell
CML/chronic myeloid leukemia
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506116300186

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