MicroRNAs and long non-coding RNAs in cartilage homeostasis and osteoarthritis
During the last decade, osteoarthritis (OA) has become one of the most prevalent musculoskeletal diseases worldwide. OA is characterized by progressive loss of articular cartilage, abnormal remodeling of subchondral bone, hyperplasia of synovial cells, and growth of osteophytes, which lead to chroni...
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| Format: | Article |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.1092776/full |
| _version_ | 1811178140952690688 |
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| author | Jingliang Gu Wu Rao Shaochuan Huo Tianyou Fan Minlei Qiu Haixia Zhu Deta Chen Xiaoping Sheng |
| author_facet | Jingliang Gu Wu Rao Shaochuan Huo Tianyou Fan Minlei Qiu Haixia Zhu Deta Chen Xiaoping Sheng |
| author_sort | Jingliang Gu |
| collection | DOAJ |
| description | During the last decade, osteoarthritis (OA) has become one of the most prevalent musculoskeletal diseases worldwide. OA is characterized by progressive loss of articular cartilage, abnormal remodeling of subchondral bone, hyperplasia of synovial cells, and growth of osteophytes, which lead to chronic pain and disability. The pathological mechanisms underlying OA initiation and progression are still poorly understood. Non-coding RNAs (ncRNAs) constitute a large portion of the transcriptome that do not encode proteins but function in numerous biological processes. Cumulating evidence has revealed a strong association between the changes in expression levels of ncRNA and the disease progression of OA. Moreover, loss- and gain-of-function studies utilizing transgenic animal models have demonstrated that ncRNAs exert vital functions in regulating cartilage homeostasis, degeneration, and regeneration, and changes in ncRNA expression can promote or decelerate the progression of OA through distinct molecular mechanisms. Recent studies highlighted the potential of ncRNAs to serve as diagnostic biomarkers, prognostic indicators, and therapeutic targets for OA. MiRNAs and lncRNAs are two major classes of ncRNAs that have been the most widely studied in cartilage tissues. In this review, we focused on miRNAs and lncRNAs and provided a comprehensive understanding of their functional roles as well as molecular mechanisms in cartilage homeostasis and OA pathogenesis. |
| first_indexed | 2024-04-11T06:13:10Z |
| format | Article |
| id | doaj.art-99b558b134da43fc993f2866f492ac49 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-11T06:13:10Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-99b558b134da43fc993f2866f492ac492022-12-22T04:41:08ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-12-011010.3389/fcell.2022.10927761092776MicroRNAs and long non-coding RNAs in cartilage homeostasis and osteoarthritisJingliang Gu0Wu Rao1Shaochuan Huo2Tianyou Fan3Minlei Qiu4Haixia Zhu5Deta Chen6Xiaoping Sheng7Department of Orthopedics, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Orthopedics, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaShenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen, ChinaDepartment of Orthopedics, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Orthopedics, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Orthopedics, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Orthopedics, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Orthopedics, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDuring the last decade, osteoarthritis (OA) has become one of the most prevalent musculoskeletal diseases worldwide. OA is characterized by progressive loss of articular cartilage, abnormal remodeling of subchondral bone, hyperplasia of synovial cells, and growth of osteophytes, which lead to chronic pain and disability. The pathological mechanisms underlying OA initiation and progression are still poorly understood. Non-coding RNAs (ncRNAs) constitute a large portion of the transcriptome that do not encode proteins but function in numerous biological processes. Cumulating evidence has revealed a strong association between the changes in expression levels of ncRNA and the disease progression of OA. Moreover, loss- and gain-of-function studies utilizing transgenic animal models have demonstrated that ncRNAs exert vital functions in regulating cartilage homeostasis, degeneration, and regeneration, and changes in ncRNA expression can promote or decelerate the progression of OA through distinct molecular mechanisms. Recent studies highlighted the potential of ncRNAs to serve as diagnostic biomarkers, prognostic indicators, and therapeutic targets for OA. MiRNAs and lncRNAs are two major classes of ncRNAs that have been the most widely studied in cartilage tissues. In this review, we focused on miRNAs and lncRNAs and provided a comprehensive understanding of their functional roles as well as molecular mechanisms in cartilage homeostasis and OA pathogenesis.https://www.frontiersin.org/articles/10.3389/fcell.2022.1092776/fullosteoarthritiscartilage homeostasismicroRNAlncRNAregeneration |
| spellingShingle | Jingliang Gu Wu Rao Shaochuan Huo Tianyou Fan Minlei Qiu Haixia Zhu Deta Chen Xiaoping Sheng MicroRNAs and long non-coding RNAs in cartilage homeostasis and osteoarthritis Frontiers in Cell and Developmental Biology osteoarthritis cartilage homeostasis microRNA lncRNA regeneration |
| title | MicroRNAs and long non-coding RNAs in cartilage homeostasis and osteoarthritis |
| title_full | MicroRNAs and long non-coding RNAs in cartilage homeostasis and osteoarthritis |
| title_fullStr | MicroRNAs and long non-coding RNAs in cartilage homeostasis and osteoarthritis |
| title_full_unstemmed | MicroRNAs and long non-coding RNAs in cartilage homeostasis and osteoarthritis |
| title_short | MicroRNAs and long non-coding RNAs in cartilage homeostasis and osteoarthritis |
| title_sort | micrornas and long non coding rnas in cartilage homeostasis and osteoarthritis |
| topic | osteoarthritis cartilage homeostasis microRNA lncRNA regeneration |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.1092776/full |
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