Modulation of Intestinal Corticotropin-Releasing Hormone Signaling by the Herbal Preparation STW 5-II: Possible Mechanisms for Irritable Bowel Syndrome Management

Modulation of Intestinal Corticotropin-Releasing Hormone Signaling by the Herbal Preparation STW 5-II: Possible Mechanisms for Irritable Bowel Syndrome Management

Corticotropin-releasing factor (CRF) mediates stress responses and alters the gut-brain axis, contributing to the pathogenesis of irritable bowel syndrome (IBS), which is recognized by abdominal pain accompanied by bowel habit disturbance. STW 5-II, a mixture of six herbal extracts, is clinically ef...

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Bibliographic Details
Main Authors: Mohamed Elbadawi, Ramy M. Ammar, Sabine Rabini, Sabine M. Klauck, Thomas Efferth
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Pharmaceuticals
Subjects:
irritable bowel syndrome
mouse intestinal organoids
corticotropin-releasing factor
gut-brain axis
tight junctions
intestinal inflammation
Online Access:https://www.mdpi.com/1424-8247/15/9/1121

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https://www.mdpi.com/1424-8247/15/9/1121

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