Total small vessel disease burden and functional outcome in patients with ischemic stroke.
<h4>Background</h4>Cerebral small vessel disease (SVD) is comprised of lacunes, cerebral microbleeds (CMBs), white matter hyperintensities (WMHs), and enlarged perivascular space (EPVS). We investigated the cumulative effect of SVD on 3-month functional outcome following ischemic stroke...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0242319 |
| _version_ | 1818579771055931392 |
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| author | Wi-Sun Ryu Sang-Wuk Jeong Dong-Eog Kim |
| author_facet | Wi-Sun Ryu Sang-Wuk Jeong Dong-Eog Kim |
| author_sort | Wi-Sun Ryu |
| collection | DOAJ |
| description | <h4>Background</h4>Cerebral small vessel disease (SVD) is comprised of lacunes, cerebral microbleeds (CMBs), white matter hyperintensities (WMHs), and enlarged perivascular space (EPVS). We investigated the cumulative effect of SVD on 3-month functional outcome following ischemic stroke using the total SVD score.<h4>Methods</h4>The total SVD score of 477 acute ischemic stroke patients with adequate brain MRI was analyzed. We used multivariable ordinal logistic regression analysis to investigate the independent impact of total SVD score on ordinal modified Rankin Scale (mRS) score at 3-month after ischemic stroke.<h4>Results</h4>Mean age was 66±14 years, and 61% were men. The distribution of the total SVD score from 0 to 4 was 27%, 24%, 26%, 16%, and 7%, respectively. The proportion of mRS scores 2 or greater was 16% and 47% in total SVD score 0 and 4, respectively. Multivariable ordinal logistic regression analysis results showed that compared with the total SVD score of 0, total SVD scores of 2, 3, and 4 were independently associated with higher mRS scores with adjusted odds ratios (95% confidence intervals) of 1.68 (1.02-2.76), 2.24 (1.25-4.00), and 2.00 (1.02-4.29). Lacunes, CMBs, WMHs but not EPVS were associated with mRS scores at 3 months. However, the impact of each SVD marker on stroke outcome was smaller than that of the total SVD score.<h4>Conclusion</h4>We found an independent association between total SVD scores and functional outcome at 3 months following ischemic stroke. The total SVD score may be useful for stratification of patients who are at a high-risk of unfavorable outcomes. |
| first_indexed | 2024-12-16T07:06:59Z |
| format | Article |
| id | doaj.art-99b6928b67f3417a81a577f8a3324654 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T07:06:59Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-99b6928b67f3417a81a577f8a33246542022-12-21T22:40:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-011511e024231910.1371/journal.pone.0242319Total small vessel disease burden and functional outcome in patients with ischemic stroke.Wi-Sun RyuSang-Wuk JeongDong-Eog Kim<h4>Background</h4>Cerebral small vessel disease (SVD) is comprised of lacunes, cerebral microbleeds (CMBs), white matter hyperintensities (WMHs), and enlarged perivascular space (EPVS). We investigated the cumulative effect of SVD on 3-month functional outcome following ischemic stroke using the total SVD score.<h4>Methods</h4>The total SVD score of 477 acute ischemic stroke patients with adequate brain MRI was analyzed. We used multivariable ordinal logistic regression analysis to investigate the independent impact of total SVD score on ordinal modified Rankin Scale (mRS) score at 3-month after ischemic stroke.<h4>Results</h4>Mean age was 66±14 years, and 61% were men. The distribution of the total SVD score from 0 to 4 was 27%, 24%, 26%, 16%, and 7%, respectively. The proportion of mRS scores 2 or greater was 16% and 47% in total SVD score 0 and 4, respectively. Multivariable ordinal logistic regression analysis results showed that compared with the total SVD score of 0, total SVD scores of 2, 3, and 4 were independently associated with higher mRS scores with adjusted odds ratios (95% confidence intervals) of 1.68 (1.02-2.76), 2.24 (1.25-4.00), and 2.00 (1.02-4.29). Lacunes, CMBs, WMHs but not EPVS were associated with mRS scores at 3 months. However, the impact of each SVD marker on stroke outcome was smaller than that of the total SVD score.<h4>Conclusion</h4>We found an independent association between total SVD scores and functional outcome at 3 months following ischemic stroke. The total SVD score may be useful for stratification of patients who are at a high-risk of unfavorable outcomes.https://doi.org/10.1371/journal.pone.0242319 |
| spellingShingle | Wi-Sun Ryu Sang-Wuk Jeong Dong-Eog Kim Total small vessel disease burden and functional outcome in patients with ischemic stroke. PLoS ONE |
| title | Total small vessel disease burden and functional outcome in patients with ischemic stroke. |
| title_full | Total small vessel disease burden and functional outcome in patients with ischemic stroke. |
| title_fullStr | Total small vessel disease burden and functional outcome in patients with ischemic stroke. |
| title_full_unstemmed | Total small vessel disease burden and functional outcome in patients with ischemic stroke. |
| title_short | Total small vessel disease burden and functional outcome in patients with ischemic stroke. |
| title_sort | total small vessel disease burden and functional outcome in patients with ischemic stroke |
| url | https://doi.org/10.1371/journal.pone.0242319 |
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