PATHOGENETIC CLASSIFICATION OF ARTERIAL HYPERTENSION FORMS
At certain phylogenesis stages, during closed circulatory system formation, the heart as a central pump was included into the peripheral peristaltic pump system of muscular type arterioles, which had been functioning for centuries. Hydrodynamic pressure, or blood pressure, could be a physical factor...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2009-04-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1343 |
| Summary: | At certain phylogenesis stages, during closed circulatory system formation, the heart as a central pump was included into the peripheral peristaltic pump system of muscular type arterioles, which had been functioning for centuries. Hydrodynamic pressure, or blood pressure, could be a physical factor regulating metabolism in the body as a whole. Cell destruction in paracrine-regulated complexes is associated with superoxide anion inactivation of NO – the regulator of peristaltic pump function. The heart compensates cell perfusion by increasing hydrodynamic pressure in intravascular pool, proportionally to peripheral resistance. Cell degradation products disturb biological endoecology, which could be restored by inflammation activation (endothelium monolayer trans-cytosis and macrophage utilisation of biological “debris” with high molecular mass), as well as by increased glomerular filtration eliminating endogenous pro-inflammatory agents of low molecular mass. Passive stages of these biological reactions are activated by hydrodynamic pressure increase. Blood pressure could be considered, therefore, as a part of the complex biological reaction of inflammation. Exotrophy disturbances could also lead to intercellular «debris» accumulation, disturbed endoecology, and compensatory inflammation. Disturbed homeostasis and passive trans-cytosis in bio-layers separating local pools in vivo (liquor, placenta, renal, and pulmonary pools) are also compensated by the heart, by increased hydrodynamic pressure in intravascular pool. Homeostasis, exotrophy, and endoecology disturbances need to be compensated by activated inflammatory reaction, heart hyper-function, and increased hydrodynamic pressure. This is the main course of increasing arterial hypertension incidence in developed countries. |
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| ISSN: | 1560-4071 2618-7620 |