Long-term follow up of a patient with a recurrent desmoid tumor that was successfully treated with proton beam therapy: A case report and literature review
Desmoid tumors are benign, but may have a locally invasive tendency that commonly results in local recurrence. Most occur on the body trunk or extremities, whereas a head and neck desmoid tumor is relatively rare. The efficacy of radiotherapy has been suggested and 50–60 Gy is used for unresectable...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-03-01
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| Series: | Clinical and Translational Radiation Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405630820301075 |
| _version_ | 1818647166579638272 |
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| author | Takuya Sawada Masashi Mizumoto Yoshiko Oshiro Haruko Numajiri Shosei Shimizu Yuichi Hiroshima Masatoshi Nakamura Takashi Iizumi Toshiyuki Okumura Hideyuki Sakurai |
| author_facet | Takuya Sawada Masashi Mizumoto Yoshiko Oshiro Haruko Numajiri Shosei Shimizu Yuichi Hiroshima Masatoshi Nakamura Takashi Iizumi Toshiyuki Okumura Hideyuki Sakurai |
| author_sort | Takuya Sawada |
| collection | DOAJ |
| description | Desmoid tumors are benign, but may have a locally invasive tendency that commonly results in local recurrence. Most occur on the body trunk or extremities, whereas a head and neck desmoid tumor is relatively rare. The efficacy of radiotherapy has been suggested and 50–60 Gy is used for unresectable or recurrent desmoid tumors, but there are few reports of use of particle beam therapy. However, since this tumor occurs more often in younger patients compared to malignant tumors and the prognosis is favorable, there may be an advantage of this therapy. We treated a male patient with a head and neck recurrent desmoid tumor with proton beam therapy (PBT) at a dose of 60 Gy (RBE). This patient underwent surgical resection as initial treatment, but the tumor recurred only six months after surgery, and resection was performed again. After PBT, the tumor gradually shrank and complete remission has been achieved for 10 years without any severe late toxicity. Here, we report the details of this case, with a review of the literature. We suggest that PBT may reduce the incidence of second malignant tumors by reducing the dose exposure around the planning target volume. |
| first_indexed | 2024-12-17T00:58:13Z |
| format | Article |
| id | doaj.art-99b9a945243c44bd8a82298cb59319f9 |
| institution | Directory Open Access Journal |
| issn | 2405-6308 |
| language | English |
| last_indexed | 2024-12-17T00:58:13Z |
| publishDate | 2021-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical and Translational Radiation Oncology |
| spelling | doaj.art-99b9a945243c44bd8a82298cb59319f92022-12-21T22:09:33ZengElsevierClinical and Translational Radiation Oncology2405-63082021-03-01273235Long-term follow up of a patient with a recurrent desmoid tumor that was successfully treated with proton beam therapy: A case report and literature reviewTakuya Sawada0Masashi Mizumoto1Yoshiko Oshiro2Haruko Numajiri3Shosei Shimizu4Yuichi Hiroshima5Masatoshi Nakamura6Takashi Iizumi7Toshiyuki Okumura8Hideyuki Sakurai9Department of Radiation Oncology, Proton Medical Research Center, University of Tsukuba Hospital, Tsukuba, Ibaraki, JapanDepartment of Radiation Oncology, Proton Medical Research Center, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan; Corresponding author at: Department of Radiation Oncology, Proton Medical Research Center, University of Tsukuba Hospital, 2-1-1 Amakubo, Tsukuba, Ibaraki 305-8576, Japan.Department of Radiation Oncology, Proton Medical Research Center, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan; Department of Radiation Oncology, Tsukuba Medical Center Hospital, Tsukuba, Ibaraki, JapanDepartment of Radiation Oncology, Proton Medical Research Center, University of Tsukuba Hospital, Tsukuba, Ibaraki, JapanDepartment of Radiation Oncology, Proton Medical Research Center, University of Tsukuba Hospital, Tsukuba, Ibaraki, JapanDepartment of Radiation Oncology, Proton Medical Research Center, University of Tsukuba Hospital, Tsukuba, Ibaraki, JapanDepartment of Radiation Oncology, Proton Medical Research Center, University of Tsukuba Hospital, Tsukuba, Ibaraki, JapanDepartment of Radiation Oncology, Proton Medical Research Center, University of Tsukuba Hospital, Tsukuba, Ibaraki, JapanDepartment of Radiation Oncology, Proton Medical Research Center, University of Tsukuba Hospital, Tsukuba, Ibaraki, JapanDepartment of Radiation Oncology, Proton Medical Research Center, University of Tsukuba Hospital, Tsukuba, Ibaraki, JapanDesmoid tumors are benign, but may have a locally invasive tendency that commonly results in local recurrence. Most occur on the body trunk or extremities, whereas a head and neck desmoid tumor is relatively rare. The efficacy of radiotherapy has been suggested and 50–60 Gy is used for unresectable or recurrent desmoid tumors, but there are few reports of use of particle beam therapy. However, since this tumor occurs more often in younger patients compared to malignant tumors and the prognosis is favorable, there may be an advantage of this therapy. We treated a male patient with a head and neck recurrent desmoid tumor with proton beam therapy (PBT) at a dose of 60 Gy (RBE). This patient underwent surgical resection as initial treatment, but the tumor recurred only six months after surgery, and resection was performed again. After PBT, the tumor gradually shrank and complete remission has been achieved for 10 years without any severe late toxicity. Here, we report the details of this case, with a review of the literature. We suggest that PBT may reduce the incidence of second malignant tumors by reducing the dose exposure around the planning target volume.http://www.sciencedirect.com/science/article/pii/S2405630820301075Desmoid tumorDesmoid fibromatosisRadiationProton beam therapy |
| spellingShingle | Takuya Sawada Masashi Mizumoto Yoshiko Oshiro Haruko Numajiri Shosei Shimizu Yuichi Hiroshima Masatoshi Nakamura Takashi Iizumi Toshiyuki Okumura Hideyuki Sakurai Long-term follow up of a patient with a recurrent desmoid tumor that was successfully treated with proton beam therapy: A case report and literature review Clinical and Translational Radiation Oncology Desmoid tumor Desmoid fibromatosis Radiation Proton beam therapy |
| title | Long-term follow up of a patient with a recurrent desmoid tumor that was successfully treated with proton beam therapy: A case report and literature review |
| title_full | Long-term follow up of a patient with a recurrent desmoid tumor that was successfully treated with proton beam therapy: A case report and literature review |
| title_fullStr | Long-term follow up of a patient with a recurrent desmoid tumor that was successfully treated with proton beam therapy: A case report and literature review |
| title_full_unstemmed | Long-term follow up of a patient with a recurrent desmoid tumor that was successfully treated with proton beam therapy: A case report and literature review |
| title_short | Long-term follow up of a patient with a recurrent desmoid tumor that was successfully treated with proton beam therapy: A case report and literature review |
| title_sort | long term follow up of a patient with a recurrent desmoid tumor that was successfully treated with proton beam therapy a case report and literature review |
| topic | Desmoid tumor Desmoid fibromatosis Radiation Proton beam therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2405630820301075 |
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