Mn doped Prussian blue nanoparticles for T1/T2 MR imaging, PA imaging and Fenton reaction enhanced mild temperature photothermal therapy of tumor
Abstract Background Combining the multimodal imaging and synergistic treatment in one platform can enhance the therapeutic efficacy and diagnosis accuracy. Results In this contribution, innovative Mn-doped Prussian blue nanoparticles (MnPB NPs) were prepared via microemulsion method. MnPB NPs demons...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-01-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-021-01235-2 |
| _version_ | 1798041152166821888 |
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| author | Quan Tao Genghan He Sheng Ye Di Zhang Zhide Zhang Li Qi Ruiyuan Liu |
| author_facet | Quan Tao Genghan He Sheng Ye Di Zhang Zhide Zhang Li Qi Ruiyuan Liu |
| author_sort | Quan Tao |
| collection | DOAJ |
| description | Abstract Background Combining the multimodal imaging and synergistic treatment in one platform can enhance the therapeutic efficacy and diagnosis accuracy. Results In this contribution, innovative Mn-doped Prussian blue nanoparticles (MnPB NPs) were prepared via microemulsion method. MnPB NPs demonstrated excellent T1 and T2 weighted magnetic resonance imaging (MRI) enhancement in vitro and in vivo. The robust absorbance in the near infrared range of MnPB NPs provides high antitumor efficacy for photothermal therapy (PTT) and photoacoustics imaging property. Moreover, with the doping of Mn, MnPB NPs exhibited excellent Fenton reaction activity for chemodynamic therapy (CDT). The favorable trimodal imaging and Fenton reaction enhanced mild temperature photothermal therapy in vitro and in vivo were further confirmed that MnPB NPs have significant positive effectiveness for integration of diagnosis and treatment tumor. Conclusions Overall, this Mn doped Prussian blue nanoplatform with multimodal imaging and chemodynamic/mild temperature photothermal co-therapy provides a reliable tool for tumor treatment. Graphical Abstract |
| first_indexed | 2024-04-11T22:17:31Z |
| format | Article |
| id | doaj.art-99be936e1b624e58946dca84077f39c2 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T22:17:31Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-99be936e1b624e58946dca84077f39c22022-12-22T04:00:19ZengBMCJournal of Nanobiotechnology1477-31552022-01-0120111410.1186/s12951-021-01235-2Mn doped Prussian blue nanoparticles for T1/T2 MR imaging, PA imaging and Fenton reaction enhanced mild temperature photothermal therapy of tumorQuan Tao0Genghan He1Sheng Ye2Di Zhang3Zhide Zhang4Li Qi5Ruiyuan Liu6Guangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical UniversityGuangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical UniversityGuangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical UniversityGuangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical UniversityGuangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical UniversityGuangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical UniversityGuangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical UniversityAbstract Background Combining the multimodal imaging and synergistic treatment in one platform can enhance the therapeutic efficacy and diagnosis accuracy. Results In this contribution, innovative Mn-doped Prussian blue nanoparticles (MnPB NPs) were prepared via microemulsion method. MnPB NPs demonstrated excellent T1 and T2 weighted magnetic resonance imaging (MRI) enhancement in vitro and in vivo. The robust absorbance in the near infrared range of MnPB NPs provides high antitumor efficacy for photothermal therapy (PTT) and photoacoustics imaging property. Moreover, with the doping of Mn, MnPB NPs exhibited excellent Fenton reaction activity for chemodynamic therapy (CDT). The favorable trimodal imaging and Fenton reaction enhanced mild temperature photothermal therapy in vitro and in vivo were further confirmed that MnPB NPs have significant positive effectiveness for integration of diagnosis and treatment tumor. Conclusions Overall, this Mn doped Prussian blue nanoplatform with multimodal imaging and chemodynamic/mild temperature photothermal co-therapy provides a reliable tool for tumor treatment. Graphical Abstracthttps://doi.org/10.1186/s12951-021-01235-2MR imagingPhotoacoustic imagingMild temperature photothermal therapyChemodynamic therapyFenton reaction |
| spellingShingle | Quan Tao Genghan He Sheng Ye Di Zhang Zhide Zhang Li Qi Ruiyuan Liu Mn doped Prussian blue nanoparticles for T1/T2 MR imaging, PA imaging and Fenton reaction enhanced mild temperature photothermal therapy of tumor Journal of Nanobiotechnology MR imaging Photoacoustic imaging Mild temperature photothermal therapy Chemodynamic therapy Fenton reaction |
| title | Mn doped Prussian blue nanoparticles for T1/T2 MR imaging, PA imaging and Fenton reaction enhanced mild temperature photothermal therapy of tumor |
| title_full | Mn doped Prussian blue nanoparticles for T1/T2 MR imaging, PA imaging and Fenton reaction enhanced mild temperature photothermal therapy of tumor |
| title_fullStr | Mn doped Prussian blue nanoparticles for T1/T2 MR imaging, PA imaging and Fenton reaction enhanced mild temperature photothermal therapy of tumor |
| title_full_unstemmed | Mn doped Prussian blue nanoparticles for T1/T2 MR imaging, PA imaging and Fenton reaction enhanced mild temperature photothermal therapy of tumor |
| title_short | Mn doped Prussian blue nanoparticles for T1/T2 MR imaging, PA imaging and Fenton reaction enhanced mild temperature photothermal therapy of tumor |
| title_sort | mn doped prussian blue nanoparticles for t1 t2 mr imaging pa imaging and fenton reaction enhanced mild temperature photothermal therapy of tumor |
| topic | MR imaging Photoacoustic imaging Mild temperature photothermal therapy Chemodynamic therapy Fenton reaction |
| url | https://doi.org/10.1186/s12951-021-01235-2 |
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