Endothelial Cell Participation in Inflammatory Reaction
Inflammation is an old concept that has started to be considered as an important factor in infection and chronic diseases. The role of leukocytes, the plasmatic components, then of the mediators such as prostaglandins, cytokines, and, in recent decades, of the endothelium has completed the concept o...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/12/6341 |
| _version_ | 1797530260860829696 |
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| author | Jean-Luc Wautier Marie-Paule Wautier |
| author_facet | Jean-Luc Wautier Marie-Paule Wautier |
| author_sort | Jean-Luc Wautier |
| collection | DOAJ |
| description | Inflammation is an old concept that has started to be considered as an important factor in infection and chronic diseases. The role of leukocytes, the plasmatic components, then of the mediators such as prostaglandins, cytokines, and, in recent decades, of the endothelium has completed the concept of the inflammation process. The function of the endothelium appeared to be crucial as a regulator or the initiator of the inflammatory process. Culture of human endothelial cells and experimental systems made it possible to define the molecular basis of inflammation in vascular diseases, in diabetes mellitus, atherosclerosis, vasculitis and thromboembolic complications. Advanced glycation end product receptor (RAGE), present on endothelial cells (ECs) and monocytes, participates in the activation of these cells in inflammatory conditions. Inflammasome is a cytosolic multiprotein that controls the response to diverse microorganisms. It is positively regulated by stimulator of interferon response CGAMP interactor-1 (STING1). Angiogenesis and thrombotic events are dysregulated during inflammation. ECs appear to be a protector, but also a possible initiator of thrombosis. |
| first_indexed | 2024-03-10T10:26:30Z |
| format | Article |
| id | doaj.art-99becd0029294f1da1ecac4ba11354c5 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:26:30Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-99becd0029294f1da1ecac4ba11354c52023-11-21T23:59:34ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012212634110.3390/ijms22126341Endothelial Cell Participation in Inflammatory ReactionJean-Luc Wautier0Marie-Paule Wautier1Faculté de Médecine, Université Denis Diderot Paris, 75013 Paris, FranceFaculté de Médecine, Université Denis Diderot Paris, 75013 Paris, FranceInflammation is an old concept that has started to be considered as an important factor in infection and chronic diseases. The role of leukocytes, the plasmatic components, then of the mediators such as prostaglandins, cytokines, and, in recent decades, of the endothelium has completed the concept of the inflammation process. The function of the endothelium appeared to be crucial as a regulator or the initiator of the inflammatory process. Culture of human endothelial cells and experimental systems made it possible to define the molecular basis of inflammation in vascular diseases, in diabetes mellitus, atherosclerosis, vasculitis and thromboembolic complications. Advanced glycation end product receptor (RAGE), present on endothelial cells (ECs) and monocytes, participates in the activation of these cells in inflammatory conditions. Inflammasome is a cytosolic multiprotein that controls the response to diverse microorganisms. It is positively regulated by stimulator of interferon response CGAMP interactor-1 (STING1). Angiogenesis and thrombotic events are dysregulated during inflammation. ECs appear to be a protector, but also a possible initiator of thrombosis.https://www.mdpi.com/1422-0067/22/12/6341endothelial cellsinflammationinflammasomeangiogenesisthrombosisSARS-CoV-2 |
| spellingShingle | Jean-Luc Wautier Marie-Paule Wautier Endothelial Cell Participation in Inflammatory Reaction International Journal of Molecular Sciences endothelial cells inflammation inflammasome angiogenesis thrombosis SARS-CoV-2 |
| title | Endothelial Cell Participation in Inflammatory Reaction |
| title_full | Endothelial Cell Participation in Inflammatory Reaction |
| title_fullStr | Endothelial Cell Participation in Inflammatory Reaction |
| title_full_unstemmed | Endothelial Cell Participation in Inflammatory Reaction |
| title_short | Endothelial Cell Participation in Inflammatory Reaction |
| title_sort | endothelial cell participation in inflammatory reaction |
| topic | endothelial cells inflammation inflammasome angiogenesis thrombosis SARS-CoV-2 |
| url | https://www.mdpi.com/1422-0067/22/12/6341 |
| work_keys_str_mv | AT jeanlucwautier endothelialcellparticipationininflammatoryreaction AT mariepaulewautier endothelialcellparticipationininflammatoryreaction |