Anti-Excitotoxic Effects of N-Butylidenephthalide Revealed by Chemically Insulted Purkinje Progenitor Cells Derived from SCA3 iPSCs

Anti-Excitotoxic Effects of N-Butylidenephthalide Revealed by Chemically Insulted Purkinje Progenitor Cells Derived from SCA3 iPSCs

Spinocerebellar ataxia type 3 (SCA3) is characterized by the over-repetitive CAG codon in the ataxin-3 gene (<i>ATXN3</i>), which encodes the mutant ATXN3 protein. The pathological defects of SCA3 such as the impaired aggresomes, autophagy, and the proteasome have been reported previousl...

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Bibliographic Details
Main Authors: Hsin-Han Yang, I-Tsang Chiang, Jen-Wei Liu, Jeanne Hsieh, Jui-Hao Lee, Huai-En Lu, Hwa-Sung Tso, Yu-Chen Deng, Jo-Chi Kao, Jhen-Rong Wu, Horng-Jyh Harn, Tzyy-Wen Chiou
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
n-butylidenephthalide
SCA3
ATXN3
iPSCs
Purkinje progenitor
quinolinic acid
Online Access:https://www.mdpi.com/1422-0067/23/3/1391

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