HIV-1 Tat and cocaine impact astrocytic energy reservoirs and epigenetic regulation by influencing the LINC01133-hsa-miR-4726-5p-NDUFA9 axis

HIV-1 Tat and cocaine impact astrocytic energy reservoirs and epigenetic regulation by influencing the LINC01133-hsa-miR-4726-5p-NDUFA9 axis

Clinical research has proven that HIV-positive (HIV+) individuals with cocaine abuse show behavioral and neurocognitive disorders. Noncoding RNAs (ncRNAs), such as long ncRNAs (lncRNAs) and microRNAs (miRNAs), are known to regulate gene expression in the contexts of HIV infection and drug abuse. How...

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Bibliographic Details
Main Authors: Mayur Doke, Jay P. McLaughlin, James J. Cai, Gurudutt Pendyala, Fatah Kashanchi, Mansoor A. Khan, Thangavel Samikkannu
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
LINC01133
hsa-miR-4726-5p
NDUFA9
cocaine
HIV-associated dementia
energy metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253122001706

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