The impact of inflammation on Resistin, IL-6 and CRP in Acute Myocardial Infarction Patients.
Background: Inflammation contributes across the spectrum of cardiovascular disease, including the earliest steps in atherogenesis. Myocardial Infarction (MI) is most commonly due to occlusion (blockage) of a coronary artery following the rupture of a vulnerable atherosclerotic plaque. It has been su...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2011-07-01
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| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/878 |
| _version_ | 1797334876132737024 |
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| author | Ammal E. Ibrahim Hadef D. EL-Yassin Hamid K. Sachit AL-Janabi |
| author_facet | Ammal E. Ibrahim Hadef D. EL-Yassin Hamid K. Sachit AL-Janabi |
| author_sort | Ammal E. Ibrahim |
| collection | DOAJ |
| description | Background: Inflammation contributes across the spectrum of cardiovascular disease, including the earliest steps in atherogenesis. Myocardial Infarction (MI) is most commonly due to occlusion (blockage) of a coronary artery following the rupture of a vulnerable atherosclerotic plaque. It has been suggested that the adipose tissue may play an important role in mediating this chronic inflammatory process, human resistin, is a 12.5-kDa protein, it found in the inflammatory zone. Interleukin-6 (IL-6) is a pro-inflammatory cytokine, it secreted by T cells and macrophages to stimulate immune response. C-reactive protein (CRP) is a protein found in the blood, the levels of CRP rise in response to inflammation.
Objective: to determine the role of Resistin in Acute myocardial infarction patients and its effects on IL-6 and CRP.
Patients and Methods: The study included 50 patients with Acute Myocardial Infarction and 40 healthy subject as control, levels of resistin, Interleukin-6 (IL-6) and CRP were measured.
Results: The levels of resistin, IL-6 and CRP were significantly elevated with (p<0.001). There was positive correlation between resistin with IL-6 and CRP in acute myocardial infarction patients.
Conclusions: There was significantly increasing in levels of resistin, in acute myocardial infarction patients and this increasing may be related to inflammation. Resistin positively correlated with proinflammatory factor (IL-6 and CRP) so it have inflammation properties may consider a cardiovascular risk factor. |
| first_indexed | 2024-03-08T08:27:35Z |
| format | Article |
| id | doaj.art-99c412840ca1416187cfb4655fbf12c3 |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T08:27:35Z |
| publishDate | 2011-07-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-99c412840ca1416187cfb4655fbf12c32024-02-02T04:16:40ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572011-07-0153210.32007/jfacmedbagdad.v2216-220%The impact of inflammation on Resistin, IL-6 and CRP in Acute Myocardial Infarction Patients.Ammal E. Ibrahim0Hadef D. EL-Yassin1Hamid K. Sachit AL-Janabi2Dept. of Physiology Chemistry, College of Medicine University of Baghdad.Dept. of Physiology Chemistry, College of Medicine University of Baghdad.Dept. of Internal Medicine, Collage of Medicine, University of Baghdad.Background: Inflammation contributes across the spectrum of cardiovascular disease, including the earliest steps in atherogenesis. Myocardial Infarction (MI) is most commonly due to occlusion (blockage) of a coronary artery following the rupture of a vulnerable atherosclerotic plaque. It has been suggested that the adipose tissue may play an important role in mediating this chronic inflammatory process, human resistin, is a 12.5-kDa protein, it found in the inflammatory zone. Interleukin-6 (IL-6) is a pro-inflammatory cytokine, it secreted by T cells and macrophages to stimulate immune response. C-reactive protein (CRP) is a protein found in the blood, the levels of CRP rise in response to inflammation. Objective: to determine the role of Resistin in Acute myocardial infarction patients and its effects on IL-6 and CRP. Patients and Methods: The study included 50 patients with Acute Myocardial Infarction and 40 healthy subject as control, levels of resistin, Interleukin-6 (IL-6) and CRP were measured. Results: The levels of resistin, IL-6 and CRP were significantly elevated with (p<0.001). There was positive correlation between resistin with IL-6 and CRP in acute myocardial infarction patients. Conclusions: There was significantly increasing in levels of resistin, in acute myocardial infarction patients and this increasing may be related to inflammation. Resistin positively correlated with proinflammatory factor (IL-6 and CRP) so it have inflammation properties may consider a cardiovascular risk factor.http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/878resistin, IL-6, CRP and Acute Myocardial Infarction. |
| spellingShingle | Ammal E. Ibrahim Hadef D. EL-Yassin Hamid K. Sachit AL-Janabi The impact of inflammation on Resistin, IL-6 and CRP in Acute Myocardial Infarction Patients. مجلة كلية الطب resistin, IL-6, CRP and Acute Myocardial Infarction. |
| title | The impact of inflammation on Resistin, IL-6 and CRP in Acute Myocardial Infarction Patients. |
| title_full | The impact of inflammation on Resistin, IL-6 and CRP in Acute Myocardial Infarction Patients. |
| title_fullStr | The impact of inflammation on Resistin, IL-6 and CRP in Acute Myocardial Infarction Patients. |
| title_full_unstemmed | The impact of inflammation on Resistin, IL-6 and CRP in Acute Myocardial Infarction Patients. |
| title_short | The impact of inflammation on Resistin, IL-6 and CRP in Acute Myocardial Infarction Patients. |
| title_sort | impact of inflammation on resistin il 6 and crp in acute myocardial infarction patients |
| topic | resistin, IL-6, CRP and Acute Myocardial Infarction. |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/878 |
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