Targeting Colorectal Cancer Stem Cells as an Effective Treatment for Colorectal Cancer
As one of the common cancers that threaten human life, the recurrence and metastasis of colorectal cancer seriously affect the prognosis of patients. Although new drugs and comprehensive treatments have been adopted, the current treatment effect on this tumor, especially in advanced colorectal cance...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2020-07-01
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| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/1533033819892261 |
| _version_ | 1818775461588631552 |
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| author | Yu-Shui Ma PhD Wen Li PhD Yu Liu MS Yi Shi MS Qin-Lu Lin PhD Da Fu PhD |
| author_facet | Yu-Shui Ma PhD Wen Li PhD Yu Liu MS Yi Shi MS Qin-Lu Lin PhD Da Fu PhD |
| author_sort | Yu-Shui Ma PhD |
| collection | DOAJ |
| description | As one of the common cancers that threaten human life, the recurrence and metastasis of colorectal cancer seriously affect the prognosis of patients. Although new drugs and comprehensive treatments have been adopted, the current treatment effect on this tumor, especially in advanced colorectal cancer, is still not satisfactory. More and more evidence shows that tumors are likely to be a stem cell disease. In recent years, the rise of cancer stem cell theory has provided a new way for cancer treatment. Studies have found that a small number of special cells in colorectal cancer tissues that induce tumorigenesis, proliferation, and promote tumor migration and metastasis, namely, colorectal cancer stem cells. Colorectal cancer stem cells are defined with a group of cell-surface markers, such as CD44, CD133, CD24, epithelial cell adhesion factor molecule, LGR5, and acetaldehyde dehydrogenase. They are highly tumorigenic, aggressive, and chemoresistant and thus are critical in the metastasis and recurrence of colorectal cancer. Therefore, targeting colorectal cancer stem cells may become an important research direction for the future cure of colorectal cancer. |
| first_indexed | 2024-12-18T10:57:25Z |
| format | Article |
| id | doaj.art-99c8871d640b464fbe7b93fe89ba05be |
| institution | Directory Open Access Journal |
| issn | 1533-0338 |
| language | English |
| last_indexed | 2024-12-18T10:57:25Z |
| publishDate | 2020-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj.art-99c8871d640b464fbe7b93fe89ba05be2022-12-21T21:10:18ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382020-07-011910.1177/1533033819892261Targeting Colorectal Cancer Stem Cells as an Effective Treatment for Colorectal CancerYu-Shui Ma PhD0Wen Li PhD1Yu Liu MS2Yi Shi MS3Qin-Lu Lin PhD4Da Fu PhD5 Central Laboratory for Medical Research, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China National Engineering Laboratory for Rice and By-Product Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, China Central Laboratory for Medical Research, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China Central Laboratory for Medical Research, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China National Engineering Laboratory for Rice and By-Product Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, China Central Laboratory for Medical Research, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaAs one of the common cancers that threaten human life, the recurrence and metastasis of colorectal cancer seriously affect the prognosis of patients. Although new drugs and comprehensive treatments have been adopted, the current treatment effect on this tumor, especially in advanced colorectal cancer, is still not satisfactory. More and more evidence shows that tumors are likely to be a stem cell disease. In recent years, the rise of cancer stem cell theory has provided a new way for cancer treatment. Studies have found that a small number of special cells in colorectal cancer tissues that induce tumorigenesis, proliferation, and promote tumor migration and metastasis, namely, colorectal cancer stem cells. Colorectal cancer stem cells are defined with a group of cell-surface markers, such as CD44, CD133, CD24, epithelial cell adhesion factor molecule, LGR5, and acetaldehyde dehydrogenase. They are highly tumorigenic, aggressive, and chemoresistant and thus are critical in the metastasis and recurrence of colorectal cancer. Therefore, targeting colorectal cancer stem cells may become an important research direction for the future cure of colorectal cancer.https://doi.org/10.1177/1533033819892261 |
| spellingShingle | Yu-Shui Ma PhD Wen Li PhD Yu Liu MS Yi Shi MS Qin-Lu Lin PhD Da Fu PhD Targeting Colorectal Cancer Stem Cells as an Effective Treatment for Colorectal Cancer Technology in Cancer Research & Treatment |
| title | Targeting Colorectal Cancer Stem Cells as an Effective Treatment for Colorectal Cancer |
| title_full | Targeting Colorectal Cancer Stem Cells as an Effective Treatment for Colorectal Cancer |
| title_fullStr | Targeting Colorectal Cancer Stem Cells as an Effective Treatment for Colorectal Cancer |
| title_full_unstemmed | Targeting Colorectal Cancer Stem Cells as an Effective Treatment for Colorectal Cancer |
| title_short | Targeting Colorectal Cancer Stem Cells as an Effective Treatment for Colorectal Cancer |
| title_sort | targeting colorectal cancer stem cells as an effective treatment for colorectal cancer |
| url | https://doi.org/10.1177/1533033819892261 |
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