Indolent T-lymphoblastic proliferation with fibrolamellar hepatocellular carcinoma developed after colorectal adenocarcinoma: a case report
Objective: Indolent T-lymphoblastic proliferation (iT-LBP) is a non-neoplastic disease with an indolent clinical course, manifesting as hyperplasia of immature extrathymic T-lymphoblastic cells. Isolated iT-LBP has been observed, but the majority of iT-LBP cases has been seen in conjunction with oth...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Pathology and Oncology Research |
| Subjects: | |
| Online Access: | https://www.por-journal.com/articles/10.3389/pore.2023.1611151/full |
| _version_ | 1797221089298874368 |
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| author | Wen Han Bei Wang Xiang Yong Yi Zhang Mingyu Shao Chun Wang |
| author_facet | Wen Han Bei Wang Xiang Yong Yi Zhang Mingyu Shao Chun Wang |
| author_sort | Wen Han |
| collection | DOAJ |
| description | Objective: Indolent T-lymphoblastic proliferation (iT-LBP) is a non-neoplastic disease with an indolent clinical course, manifesting as hyperplasia of immature extrathymic T-lymphoblastic cells. Isolated iT-LBP has been observed, but the majority of iT-LBP cases has been seen in conjunction with other diseases. iT-LBP is easily misdiagnosed as T-lymphoblastic lymphoma/leukemia, and understanding the disease of indolent T-lymphoblastic proliferation may prevent misdiagnosis and missed diagnosis in pathological diagnosis.Case presentation: We report a case morphology, immunophenotypic, and molecular features of iT-LBP combined with fibrolamellar hepatocellular carcinoma developed after colorectal adenocarcinoma and review relevant literature.Conclusion: iT-LBP combined with fibrolamellar hepatocellular carcinoma developed after colorectal adenocarcinoma is relatively rare and should always be considered as a differential diagnosis of T-lymphoblastic lymphoma and scirrhous hepatocellular carcinoma as the two disorders show highly similar clinical features. |
| first_indexed | 2024-04-24T12:59:53Z |
| format | Article |
| id | doaj.art-99c9a3166e7f40f192801a7997612f3c |
| institution | Directory Open Access Journal |
| issn | 1532-2807 |
| language | English |
| last_indexed | 2024-04-24T12:59:53Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Pathology and Oncology Research |
| spelling | doaj.art-99c9a3166e7f40f192801a7997612f3c2024-04-05T16:15:46ZengFrontiers Media S.A.Pathology and Oncology Research1532-28072023-05-012910.3389/pore.2023.16111511611151Indolent T-lymphoblastic proliferation with fibrolamellar hepatocellular carcinoma developed after colorectal adenocarcinoma: a case reportWen Han0Bei Wang1Xiang Yong2Yi Zhang3Mingyu Shao4Chun Wang5Department of Pathology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, ChinaGraduate Education Department, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, ChinaDepartment of Pathology, Anhui Wanbei Coal-Electricity Group General Hospital, Suzhou, ChinaDepartment of Pathology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, ChinaDepartment of Pathology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, ChinaDepartment of Pathology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, ChinaObjective: Indolent T-lymphoblastic proliferation (iT-LBP) is a non-neoplastic disease with an indolent clinical course, manifesting as hyperplasia of immature extrathymic T-lymphoblastic cells. Isolated iT-LBP has been observed, but the majority of iT-LBP cases has been seen in conjunction with other diseases. iT-LBP is easily misdiagnosed as T-lymphoblastic lymphoma/leukemia, and understanding the disease of indolent T-lymphoblastic proliferation may prevent misdiagnosis and missed diagnosis in pathological diagnosis.Case presentation: We report a case morphology, immunophenotypic, and molecular features of iT-LBP combined with fibrolamellar hepatocellular carcinoma developed after colorectal adenocarcinoma and review relevant literature.Conclusion: iT-LBP combined with fibrolamellar hepatocellular carcinoma developed after colorectal adenocarcinoma is relatively rare and should always be considered as a differential diagnosis of T-lymphoblastic lymphoma and scirrhous hepatocellular carcinoma as the two disorders show highly similar clinical features.https://www.por-journal.com/articles/10.3389/pore.2023.1611151/fulldifferential diagnosisindolent T-lymphoblastic proliferationiT-LBPfibrolamellar hepatocellular carcinomaT-lymphoblastic lymphoma |
| spellingShingle | Wen Han Bei Wang Xiang Yong Yi Zhang Mingyu Shao Chun Wang Indolent T-lymphoblastic proliferation with fibrolamellar hepatocellular carcinoma developed after colorectal adenocarcinoma: a case report Pathology and Oncology Research differential diagnosis indolent T-lymphoblastic proliferation iT-LBP fibrolamellar hepatocellular carcinoma T-lymphoblastic lymphoma |
| title | Indolent T-lymphoblastic proliferation with fibrolamellar hepatocellular carcinoma developed after colorectal adenocarcinoma: a case report |
| title_full | Indolent T-lymphoblastic proliferation with fibrolamellar hepatocellular carcinoma developed after colorectal adenocarcinoma: a case report |
| title_fullStr | Indolent T-lymphoblastic proliferation with fibrolamellar hepatocellular carcinoma developed after colorectal adenocarcinoma: a case report |
| title_full_unstemmed | Indolent T-lymphoblastic proliferation with fibrolamellar hepatocellular carcinoma developed after colorectal adenocarcinoma: a case report |
| title_short | Indolent T-lymphoblastic proliferation with fibrolamellar hepatocellular carcinoma developed after colorectal adenocarcinoma: a case report |
| title_sort | indolent t lymphoblastic proliferation with fibrolamellar hepatocellular carcinoma developed after colorectal adenocarcinoma a case report |
| topic | differential diagnosis indolent T-lymphoblastic proliferation iT-LBP fibrolamellar hepatocellular carcinoma T-lymphoblastic lymphoma |
| url | https://www.por-journal.com/articles/10.3389/pore.2023.1611151/full |
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