Genetic polymorphism and chronic obstructive pulmonary disease
Cunhua Yuan,1 De Chang,2 Guangming Lu,3 Xiaowei Deng1 1Health Medical Center, 2Department of Respiratory Medicine, General Hospital of Chinese People’s Armed Police Forces, 3Institute of Health Management, Chinese PLA General Hospital, Beijing, People’s Republic of China Abstra...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2017-05-01
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| Series: | International Journal of COPD |
| Subjects: | |
| Online Access: | https://www.dovepress.com/genetic-polymorphism-and-chronic-obstructive-pulmonary-disease-peer-reviewed-article-COPD |
| _version_ | 1818278304043499520 |
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| author | Yuan CH Chang D Lu GM Deng XW |
| author_facet | Yuan CH Chang D Lu GM Deng XW |
| author_sort | Yuan CH |
| collection | DOAJ |
| description | Cunhua Yuan,1 De Chang,2 Guangming Lu,3 Xiaowei Deng1 1Health Medical Center, 2Department of Respiratory Medicine, General Hospital of Chinese People’s Armed Police Forces, 3Institute of Health Management, Chinese PLA General Hospital, Beijing, People’s Republic of China Abstract: Chronic obstructive pulmonary disease (COPD) is a common chronic disease, and its morbidity and mortality are increasing. There are many studies that have tried to explain the pathogenesis of COPD from genetic susceptibility, to identify the susceptibility of COPD factors, which play a role in early prevention, early detection and the early treatment. However, it is well known that COPD is an inflammatory disease characterized by incomplete reversible airflow limitation in which genes interact with the environment. In recent years, many studies have proved gene polymorphisms and COPD correlation. However, there is less research on the relationship between COPD and genome-wide association study (GWAS), epigenetics and apoptosis. In this paper, we summarized the correlation between gene level and COPD from the following four aspects: the GWAS, the gene polymorphism, the epigenetics and the apoptosis, and the relationship between COPD and gene is summarized comprehensively. Keywords: chronic obstructive pulmonary disease, COPD, genetic polymorphism, genome-wide association study |
| first_indexed | 2024-12-12T23:15:18Z |
| format | Article |
| id | doaj.art-99cb9e0fff3f4a0eb4bb04b48371a500 |
| institution | Directory Open Access Journal |
| issn | 1178-2005 |
| language | English |
| last_indexed | 2024-12-12T23:15:18Z |
| publishDate | 2017-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of COPD |
| spelling | doaj.art-99cb9e0fff3f4a0eb4bb04b48371a5002022-12-22T00:08:29ZengDove Medical PressInternational Journal of COPD1178-20052017-05-01Volume 121385139332784Genetic polymorphism and chronic obstructive pulmonary diseaseYuan CHChang DLu GMDeng XWCunhua Yuan,1 De Chang,2 Guangming Lu,3 Xiaowei Deng1 1Health Medical Center, 2Department of Respiratory Medicine, General Hospital of Chinese People’s Armed Police Forces, 3Institute of Health Management, Chinese PLA General Hospital, Beijing, People’s Republic of China Abstract: Chronic obstructive pulmonary disease (COPD) is a common chronic disease, and its morbidity and mortality are increasing. There are many studies that have tried to explain the pathogenesis of COPD from genetic susceptibility, to identify the susceptibility of COPD factors, which play a role in early prevention, early detection and the early treatment. However, it is well known that COPD is an inflammatory disease characterized by incomplete reversible airflow limitation in which genes interact with the environment. In recent years, many studies have proved gene polymorphisms and COPD correlation. However, there is less research on the relationship between COPD and genome-wide association study (GWAS), epigenetics and apoptosis. In this paper, we summarized the correlation between gene level and COPD from the following four aspects: the GWAS, the gene polymorphism, the epigenetics and the apoptosis, and the relationship between COPD and gene is summarized comprehensively. Keywords: chronic obstructive pulmonary disease, COPD, genetic polymorphism, genome-wide association studyhttps://www.dovepress.com/genetic-polymorphism-and-chronic-obstructive-pulmonary-disease-peer-reviewed-article-COPDCOPD;Genetic polymorphism |
| spellingShingle | Yuan CH Chang D Lu GM Deng XW Genetic polymorphism and chronic obstructive pulmonary disease International Journal of COPD COPD;Genetic polymorphism |
| title | Genetic polymorphism and chronic obstructive pulmonary disease |
| title_full | Genetic polymorphism and chronic obstructive pulmonary disease |
| title_fullStr | Genetic polymorphism and chronic obstructive pulmonary disease |
| title_full_unstemmed | Genetic polymorphism and chronic obstructive pulmonary disease |
| title_short | Genetic polymorphism and chronic obstructive pulmonary disease |
| title_sort | genetic polymorphism and chronic obstructive pulmonary disease |
| topic | COPD;Genetic polymorphism |
| url | https://www.dovepress.com/genetic-polymorphism-and-chronic-obstructive-pulmonary-disease-peer-reviewed-article-COPD |
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