Serotonergic regulation of bipolar cell survival in the developing cerebral cortex
Summary: One key factor underlying the functional balance of cortical networks is the ratio of excitatory and inhibitory neurons. The mechanisms controlling the ultimate number of interneurons are beginning to be elucidated, but to what extent similar principles govern the survival of the large dive...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124722008312 |
| _version_ | 1828465314276311040 |
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| author | Fong Kuan Wong Martijn Selten Claudia Rosés-Novella Varun Sreenivasan Noemí Pallas-Bazarra Eleni Serafeimidou-Pouliou Alicia Hanusz-Godoy Fazal Oozeer Robert Edwards Oscar Marín |
| author_facet | Fong Kuan Wong Martijn Selten Claudia Rosés-Novella Varun Sreenivasan Noemí Pallas-Bazarra Eleni Serafeimidou-Pouliou Alicia Hanusz-Godoy Fazal Oozeer Robert Edwards Oscar Marín |
| author_sort | Fong Kuan Wong |
| collection | DOAJ |
| description | Summary: One key factor underlying the functional balance of cortical networks is the ratio of excitatory and inhibitory neurons. The mechanisms controlling the ultimate number of interneurons are beginning to be elucidated, but to what extent similar principles govern the survival of the large diversity of cortical inhibitory cells remains to be investigated. Here, we investigate the mechanisms regulating developmental cell death in neurogliaform cells, bipolar cells, and basket cells, the three main populations of interneurons originating from the caudal ganglionic eminence and the preoptic region. We found that all three subclasses of interneurons undergo activity-dependent programmed cell death. However, while neurogliaform cells and basket cells require glutamatergic transmission to survive, the final number of bipolar cells is instead modulated by serotonergic signaling. Together, our results demonstrate that input-specific modulation of neuronal activity controls the survival of cortical interneurons during the critical period of programmed cell death. |
| first_indexed | 2024-12-11T03:30:33Z |
| format | Article |
| id | doaj.art-99cc48bd03b44bcd9d850f3cdc25280c |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-11T03:30:33Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-99cc48bd03b44bcd9d850f3cdc25280c2022-12-22T01:22:24ZengElsevierCell Reports2211-12472022-07-01401111037Serotonergic regulation of bipolar cell survival in the developing cerebral cortexFong Kuan Wong0Martijn Selten1Claudia Rosés-Novella2Varun Sreenivasan3Noemí Pallas-Bazarra4Eleni Serafeimidou-Pouliou5Alicia Hanusz-Godoy6Fazal Oozeer7Robert Edwards8Oscar Marín9Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE1 1UL, UK; MRC Centre for Neurodevelopmental Disorders, King’s College London, London SE1 1UL, UKCentre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE1 1UL, UK; MRC Centre for Neurodevelopmental Disorders, King’s College London, London SE1 1UL, UKCentre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE1 1UL, UK; MRC Centre for Neurodevelopmental Disorders, King’s College London, London SE1 1UL, UKCentre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE1 1UL, UK; MRC Centre for Neurodevelopmental Disorders, King’s College London, London SE1 1UL, UKCentre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE1 1UL, UK; MRC Centre for Neurodevelopmental Disorders, King’s College London, London SE1 1UL, UKCentre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE1 1UL, UK; MRC Centre for Neurodevelopmental Disorders, King’s College London, London SE1 1UL, UKCentre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE1 1UL, UK; MRC Centre for Neurodevelopmental Disorders, King’s College London, London SE1 1UL, UKCentre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE1 1UL, UK; MRC Centre for Neurodevelopmental Disorders, King’s College London, London SE1 1UL, UKDepartment of Physiology and Department of Neurology, School of Medicine, University of California San Francisco, San Francisco, CA, USACentre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE1 1UL, UK; MRC Centre for Neurodevelopmental Disorders, King’s College London, London SE1 1UL, UK; Corresponding authorSummary: One key factor underlying the functional balance of cortical networks is the ratio of excitatory and inhibitory neurons. The mechanisms controlling the ultimate number of interneurons are beginning to be elucidated, but to what extent similar principles govern the survival of the large diversity of cortical inhibitory cells remains to be investigated. Here, we investigate the mechanisms regulating developmental cell death in neurogliaform cells, bipolar cells, and basket cells, the three main populations of interneurons originating from the caudal ganglionic eminence and the preoptic region. We found that all three subclasses of interneurons undergo activity-dependent programmed cell death. However, while neurogliaform cells and basket cells require glutamatergic transmission to survive, the final number of bipolar cells is instead modulated by serotonergic signaling. Together, our results demonstrate that input-specific modulation of neuronal activity controls the survival of cortical interneurons during the critical period of programmed cell death.http://www.sciencedirect.com/science/article/pii/S2211124722008312CP: NeuroscienceCP: Developmental biology |
| spellingShingle | Fong Kuan Wong Martijn Selten Claudia Rosés-Novella Varun Sreenivasan Noemí Pallas-Bazarra Eleni Serafeimidou-Pouliou Alicia Hanusz-Godoy Fazal Oozeer Robert Edwards Oscar Marín Serotonergic regulation of bipolar cell survival in the developing cerebral cortex Cell Reports CP: Neuroscience CP: Developmental biology |
| title | Serotonergic regulation of bipolar cell survival in the developing cerebral cortex |
| title_full | Serotonergic regulation of bipolar cell survival in the developing cerebral cortex |
| title_fullStr | Serotonergic regulation of bipolar cell survival in the developing cerebral cortex |
| title_full_unstemmed | Serotonergic regulation of bipolar cell survival in the developing cerebral cortex |
| title_short | Serotonergic regulation of bipolar cell survival in the developing cerebral cortex |
| title_sort | serotonergic regulation of bipolar cell survival in the developing cerebral cortex |
| topic | CP: Neuroscience CP: Developmental biology |
| url | http://www.sciencedirect.com/science/article/pii/S2211124722008312 |
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