Research Advances on the Damage Mechanism of Skin Glycation and Related Inhibitors
Our skin is an organ with the largest contact area between the human body and the external environment. Skin aging is affected directly by both endogenous factors and exogenous factors (e.g., UV exposure). Skin saccharification, a non-enzymatic reaction between proteins, e.g., dermal collagen and na...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/21/4588 |
| _version_ | 1797466910112088064 |
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| author | Wenge Zheng Huijuan Li Yuyo Go Xi Hui (Felicia) Chan Qing Huang Jianxin Wu |
| author_facet | Wenge Zheng Huijuan Li Yuyo Go Xi Hui (Felicia) Chan Qing Huang Jianxin Wu |
| author_sort | Wenge Zheng |
| collection | DOAJ |
| description | Our skin is an organ with the largest contact area between the human body and the external environment. Skin aging is affected directly by both endogenous factors and exogenous factors (e.g., UV exposure). Skin saccharification, a non-enzymatic reaction between proteins, e.g., dermal collagen and naturally occurring reducing sugars, is one of the basic root causes of endogenous skin aging. During the reaction, a series of complicated glycation products produced at different reaction stages and pathways are usually collectively referred to as advanced glycation end products (AGEs). AGEs cause cellular dysfunction through the modification of intracellular molecules and accumulate in tissues with aging. AGEs are also associated with a variety of age-related diseases, such as diabetes, cardiovascular disease, renal failure (uremia), and Alzheimer’s disease. AGEs accumulate in the skin with age and are amplified through exogenous factors, e.g., ultraviolet radiation, resulting in wrinkles, loss of elasticity, dull yellowing, and other skin problems. This article focuses on the damage mechanism of glucose and its glycation products on the skin by summarizing the biochemical characteristics, compositions, as well as processes of the production and elimination of AGEs. One of the important parts of this article would be to summarize the current AGEs inhibitors to gain insight into the anti-glycation mechanism of the skin and the development of promising natural products with anti-glycation effects. |
| first_indexed | 2024-03-09T18:46:11Z |
| format | Article |
| id | doaj.art-99cc51ca09714899862761b237faf86c |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T18:46:11Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-99cc51ca09714899862761b237faf86c2023-11-24T06:13:58ZengMDPI AGNutrients2072-66432022-11-011421458810.3390/nu14214588Research Advances on the Damage Mechanism of Skin Glycation and Related InhibitorsWenge Zheng0Huijuan Li1Yuyo Go2Xi Hui (Felicia) Chan3Qing Huang4Jianxin Wu5Skin Health and Cosmetic Development & Evaluation Laboratory, China Pharmaceutical University, Nanjing 210009, ChinaSkin Health and Cosmetic Development & Evaluation Laboratory, China Pharmaceutical University, Nanjing 210009, ChinaRoyal Victoria Hospital, BT12 6BA Belfast, Northern Ireland, UKRoyal Victoria Hospital, BT12 6BA Belfast, Northern Ireland, UKSkin Health and Cosmetic Development & Evaluation Laboratory, China Pharmaceutical University, Nanjing 210009, ChinaSkin Health and Cosmetic Development & Evaluation Laboratory, China Pharmaceutical University, Nanjing 210009, ChinaOur skin is an organ with the largest contact area between the human body and the external environment. Skin aging is affected directly by both endogenous factors and exogenous factors (e.g., UV exposure). Skin saccharification, a non-enzymatic reaction between proteins, e.g., dermal collagen and naturally occurring reducing sugars, is one of the basic root causes of endogenous skin aging. During the reaction, a series of complicated glycation products produced at different reaction stages and pathways are usually collectively referred to as advanced glycation end products (AGEs). AGEs cause cellular dysfunction through the modification of intracellular molecules and accumulate in tissues with aging. AGEs are also associated with a variety of age-related diseases, such as diabetes, cardiovascular disease, renal failure (uremia), and Alzheimer’s disease. AGEs accumulate in the skin with age and are amplified through exogenous factors, e.g., ultraviolet radiation, resulting in wrinkles, loss of elasticity, dull yellowing, and other skin problems. This article focuses on the damage mechanism of glucose and its glycation products on the skin by summarizing the biochemical characteristics, compositions, as well as processes of the production and elimination of AGEs. One of the important parts of this article would be to summarize the current AGEs inhibitors to gain insight into the anti-glycation mechanism of the skin and the development of promising natural products with anti-glycation effects.https://www.mdpi.com/2072-6643/14/21/4588skin glycationadvanced glycation end products (AGEs)anti-glycationAGEs inhibitors |
| spellingShingle | Wenge Zheng Huijuan Li Yuyo Go Xi Hui (Felicia) Chan Qing Huang Jianxin Wu Research Advances on the Damage Mechanism of Skin Glycation and Related Inhibitors Nutrients skin glycation advanced glycation end products (AGEs) anti-glycation AGEs inhibitors |
| title | Research Advances on the Damage Mechanism of Skin Glycation and Related Inhibitors |
| title_full | Research Advances on the Damage Mechanism of Skin Glycation and Related Inhibitors |
| title_fullStr | Research Advances on the Damage Mechanism of Skin Glycation and Related Inhibitors |
| title_full_unstemmed | Research Advances on the Damage Mechanism of Skin Glycation and Related Inhibitors |
| title_short | Research Advances on the Damage Mechanism of Skin Glycation and Related Inhibitors |
| title_sort | research advances on the damage mechanism of skin glycation and related inhibitors |
| topic | skin glycation advanced glycation end products (AGEs) anti-glycation AGEs inhibitors |
| url | https://www.mdpi.com/2072-6643/14/21/4588 |
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