Safety and Immunogenicity of an <i>In Vivo</i> Muscle Electroporation Delivery System for DNA-<i>hsp65</i> Tuberculosis Vaccine in Cynomolgus Monkeys

Safety and Immunogenicity of an <i>In Vivo</i> Muscle Electroporation Delivery System for DNA-<i>hsp65</i> Tuberculosis Vaccine in Cynomolgus Monkeys

A Bacille Calmette–Guérin (BCG) is still the only licensed vaccine for the prevention of tuberculosis, providing limited protection against Mycobacterium tuberculosis infection in adulthood. New advances in the delivery of DNA vaccines by electroporation have been made in the past decade. We evaluat...

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Bibliographic Details
Main Authors: Monique Ribeiro de Lima, Ana Cristina C. S. Leandro, Andreia Lamoglia de Souza, Marcio Mantuano Barradas, Eric Henrique Roma, Ana Teresa Gomes Fernandes, Gabrielle Galdino-Silva, Joyce Katiuccia M. Ramos Carvalho, Renato Sergio Marchevsky, Janice M. C. Oliveira Coelho, Eduardo Dantas Casillo Gonçalves, John L. VandeBerg, Celio Lopes Silva, Maria da Gloria Bonecini-Almeida
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Vaccines
Subjects:
tuberculosis
electroporation
vaccine
DNA-hsp65
safety
immunogenicity
Online Access:https://www.mdpi.com/2076-393X/11/12/1863

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