Injectable Thermo-Sensitive Chitosan Hydrogel Containing CPT-11-Loaded EGFR-Targeted Graphene Oxide and SLP2 shRNA for Localized Drug/Gene Delivery in Glioblastoma Therapy

Injectable Thermo-Sensitive Chitosan Hydrogel Containing CPT-11-Loaded EGFR-Targeted Graphene Oxide and SLP2 shRNA for Localized Drug/Gene Delivery in Glioblastoma Therapy

In this study, we aimed to develop a multifunctional drug/gene delivery system for the treatment of glioblastoma multiforme by combining the ligand-mediated active targeting and the pH-triggered drug release features of graphene oxide (GO). Toward this end, we load irinotecan (CPT-11) to cetuximab (...

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Bibliographic Details
Main Authors: Yu-Jen Lu, Yu-Hsiang Lan, Chi-Cheng Chuang, Wan-Ting Lu, Li-Yang Chan, Peng-Wei Hsu, Jyh-Ping Chen
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
hydrogel
drug delivery
cancer therapy
nanomedicine
chitosan
graphene oxide
Online Access:https://www.mdpi.com/1422-0067/21/19/7111

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