The Histopathological Types and Distribution Characteristics of Gastric Mixed Tumors
ObjectiveThe present study aimed to investigate the histopathological types and distribution characteristics of gastric mixed tumors.MethodsDetailed histological observations, together with related immunohistochemical and genetic tests, were analyzed on 960 surgically resected samples in 6 hospitals...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.873005/full |
| _version_ | 1811337661414113280 |
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| author | Fang-Heng Zhu Yang-Kun Wang Jun-Ling Zhou Nian-Long Meng Yue Wang Bo Jiang Su-Nan Wang |
| author_facet | Fang-Heng Zhu Yang-Kun Wang Jun-Ling Zhou Nian-Long Meng Yue Wang Bo Jiang Su-Nan Wang |
| author_sort | Fang-Heng Zhu |
| collection | DOAJ |
| description | ObjectiveThe present study aimed to investigate the histopathological types and distribution characteristics of gastric mixed tumors.MethodsDetailed histological observations, together with related immunohistochemical and genetic tests, were analyzed on 960 surgically resected samples in 6 hospitals with gastric mixed tumors from May 2017 to May 2021 in this retrospective study.ResultsEpithelial-derived tumors accounted for 80.10% (769/960) of the gastric mixed tumor samples studied, and tumors of different tissue origins accounting for 10.83% (104/960), mesenchymal-derived tumors accounting for 6.25% (60/960), neuroendocrine tumors accounting for 2.40% (23/960), and lymphoma accounting for 0.42% (4/960). The histological types of gastric mixed tumors identified as most commonly were epithelial originated, followed by mixed tumors of different tissue originated, then mixed neuroendocrine, lymphoma, and mesenchymal originated in sequence. The histological number of gastric mixed tumors was ≤ 3 in 83.23% (799/960) of cases and > 4 in 16.77% (161/960) of cases. The mixed histological patterns of gastric mixed tumors were divided into three types: those with tumor cells interspersed with each other, those with incomplete fibrous tissue separation, and those without fibrous tissue separation. The gene target characteristics of gastric mixed tumors were the existence of multi-gene mutation, including human epidermalgrowth factor receptor-2 (HER2) gene amplification, key result areas (K-ras) and platelet-derived growth factor receptor alpha (PDGFRA).ConclusionGastric mixed tumors should be adequately sampled, each piece of tissue should be involved in the morphological proportional division of the tumor, and any independent histological component should be written into the pathological examination report. |
| first_indexed | 2024-04-13T17:58:03Z |
| format | Article |
| id | doaj.art-99ce457d3a594749a2ca6dc7e44de7fc |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T17:58:03Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-99ce457d3a594749a2ca6dc7e44de7fc2022-12-22T02:36:22ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-06-011210.3389/fonc.2022.873005873005The Histopathological Types and Distribution Characteristics of Gastric Mixed TumorsFang-Heng Zhu0Yang-Kun Wang1Jun-Ling Zhou2Nian-Long Meng3Yue Wang4Bo Jiang5Su-Nan Wang6Department of Pathology, Xinxiang Central Hospital, Xinxiang, ChinaDepartment of Pathology, Foresea Life Insurance Guangzhou General Hospital, Guangzhou, ChinaShenzhen Nanshan District People’s Hospital, Shenzhen, ChinaDepartment of Pathology, The 989th Hospital of the Joint Logistics Support Force of The Chinese People’s Liberation Army, Luoyang, ChinaShenzhen Hezheng Hospital, Shenzhen, ChinaDepartment of Pathology, People’s Liberation Army Joint Logistic Support Force 990th Hospital, Zhumadian, ChinaShenzhen Polytechnic, Shenzhen, ChinaObjectiveThe present study aimed to investigate the histopathological types and distribution characteristics of gastric mixed tumors.MethodsDetailed histological observations, together with related immunohistochemical and genetic tests, were analyzed on 960 surgically resected samples in 6 hospitals with gastric mixed tumors from May 2017 to May 2021 in this retrospective study.ResultsEpithelial-derived tumors accounted for 80.10% (769/960) of the gastric mixed tumor samples studied, and tumors of different tissue origins accounting for 10.83% (104/960), mesenchymal-derived tumors accounting for 6.25% (60/960), neuroendocrine tumors accounting for 2.40% (23/960), and lymphoma accounting for 0.42% (4/960). The histological types of gastric mixed tumors identified as most commonly were epithelial originated, followed by mixed tumors of different tissue originated, then mixed neuroendocrine, lymphoma, and mesenchymal originated in sequence. The histological number of gastric mixed tumors was ≤ 3 in 83.23% (799/960) of cases and > 4 in 16.77% (161/960) of cases. The mixed histological patterns of gastric mixed tumors were divided into three types: those with tumor cells interspersed with each other, those with incomplete fibrous tissue separation, and those without fibrous tissue separation. The gene target characteristics of gastric mixed tumors were the existence of multi-gene mutation, including human epidermalgrowth factor receptor-2 (HER2) gene amplification, key result areas (K-ras) and platelet-derived growth factor receptor alpha (PDGFRA).ConclusionGastric mixed tumors should be adequately sampled, each piece of tissue should be involved in the morphological proportional division of the tumor, and any independent histological component should be written into the pathological examination report.https://www.frontiersin.org/articles/10.3389/fonc.2022.873005/fullgastric tumormixed tumormixed tissue typemixed organizationgene target type |
| spellingShingle | Fang-Heng Zhu Yang-Kun Wang Jun-Ling Zhou Nian-Long Meng Yue Wang Bo Jiang Su-Nan Wang The Histopathological Types and Distribution Characteristics of Gastric Mixed Tumors Frontiers in Oncology gastric tumor mixed tumor mixed tissue type mixed organization gene target type |
| title | The Histopathological Types and Distribution Characteristics of Gastric Mixed Tumors |
| title_full | The Histopathological Types and Distribution Characteristics of Gastric Mixed Tumors |
| title_fullStr | The Histopathological Types and Distribution Characteristics of Gastric Mixed Tumors |
| title_full_unstemmed | The Histopathological Types and Distribution Characteristics of Gastric Mixed Tumors |
| title_short | The Histopathological Types and Distribution Characteristics of Gastric Mixed Tumors |
| title_sort | histopathological types and distribution characteristics of gastric mixed tumors |
| topic | gastric tumor mixed tumor mixed tissue type mixed organization gene target type |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.873005/full |
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