Role of NF-κB in Ageing and Age-Related Diseases: Lessons from Genetically Modified Mouse Models
Ageing is a complex process, induced by multifaceted interaction of genetic, epigenetic, and environmental factors. It is manifested by a decline in the physiological functions of organisms and associated to the development of age-related chronic diseases and cancer development. It is considered tha...
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| Format: | Article |
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MDPI AG
2021-07-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/8/1906 |
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| author | Verónica A. García-García Josefa P. Alameda Angustias Page María Llanos Casanova |
| author_facet | Verónica A. García-García Josefa P. Alameda Angustias Page María Llanos Casanova |
| author_sort | Verónica A. García-García |
| collection | DOAJ |
| description | Ageing is a complex process, induced by multifaceted interaction of genetic, epigenetic, and environmental factors. It is manifested by a decline in the physiological functions of organisms and associated to the development of age-related chronic diseases and cancer development. It is considered that ageing follows a strictly-regulated program, in which some signaling pathways critically contribute to the establishment and maintenance of the aged state. Chronic inflammation is a major mechanism that promotes the biological ageing process and comorbidity, with the transcription factor NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) as a crucial mediator of inflammatory responses. This, together with the finding that the activation or inhibition of NF-κB can induce or reverse respectively the main features of aged organisms, has brought it under consideration as a key transcription factor that acts as a driver of ageing. In this review, we focused on the data obtained entirely through the generation of knockout and transgenic mouse models of either protein involved in the NF-κB signaling pathway that have provided relevant information about the intricate processes or molecular mechanisms that control ageing. We have reviewed the relationship of NF-κB and premature ageing; the development of cancer associated with ageing and the implication of NF-κB activation in the development of age-related diseases, some of which greatly increase the risk of developing cancer. |
| first_indexed | 2024-03-10T08:55:42Z |
| format | Article |
| id | doaj.art-99ce876df7ba4b31aa43b3cb9e972f06 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T08:55:42Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-99ce876df7ba4b31aa43b3cb9e972f062023-11-22T07:09:00ZengMDPI AGCells2073-44092021-07-01108190610.3390/cells10081906Role of NF-κB in Ageing and Age-Related Diseases: Lessons from Genetically Modified Mouse ModelsVerónica A. García-García0Josefa P. Alameda1Angustias Page2María Llanos Casanova3Molecular and Translational Oncology Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), 28040 Madrid, SpainMolecular and Translational Oncology Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), 28040 Madrid, SpainMolecular and Translational Oncology Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), 28040 Madrid, SpainMolecular and Translational Oncology Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), 28040 Madrid, SpainAgeing is a complex process, induced by multifaceted interaction of genetic, epigenetic, and environmental factors. It is manifested by a decline in the physiological functions of organisms and associated to the development of age-related chronic diseases and cancer development. It is considered that ageing follows a strictly-regulated program, in which some signaling pathways critically contribute to the establishment and maintenance of the aged state. Chronic inflammation is a major mechanism that promotes the biological ageing process and comorbidity, with the transcription factor NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) as a crucial mediator of inflammatory responses. This, together with the finding that the activation or inhibition of NF-κB can induce or reverse respectively the main features of aged organisms, has brought it under consideration as a key transcription factor that acts as a driver of ageing. In this review, we focused on the data obtained entirely through the generation of knockout and transgenic mouse models of either protein involved in the NF-κB signaling pathway that have provided relevant information about the intricate processes or molecular mechanisms that control ageing. We have reviewed the relationship of NF-κB and premature ageing; the development of cancer associated with ageing and the implication of NF-κB activation in the development of age-related diseases, some of which greatly increase the risk of developing cancer.https://www.mdpi.com/2073-4409/10/8/1906ageingage-related diseasescancerNF-κBtransgenic mouse models of NF-κB |
| spellingShingle | Verónica A. García-García Josefa P. Alameda Angustias Page María Llanos Casanova Role of NF-κB in Ageing and Age-Related Diseases: Lessons from Genetically Modified Mouse Models Cells ageing age-related diseases cancer NF-κB transgenic mouse models of NF-κB |
| title | Role of NF-κB in Ageing and Age-Related Diseases: Lessons from Genetically Modified Mouse Models |
| title_full | Role of NF-κB in Ageing and Age-Related Diseases: Lessons from Genetically Modified Mouse Models |
| title_fullStr | Role of NF-κB in Ageing and Age-Related Diseases: Lessons from Genetically Modified Mouse Models |
| title_full_unstemmed | Role of NF-κB in Ageing and Age-Related Diseases: Lessons from Genetically Modified Mouse Models |
| title_short | Role of NF-κB in Ageing and Age-Related Diseases: Lessons from Genetically Modified Mouse Models |
| title_sort | role of nf κb in ageing and age related diseases lessons from genetically modified mouse models |
| topic | ageing age-related diseases cancer NF-κB transgenic mouse models of NF-κB |
| url | https://www.mdpi.com/2073-4409/10/8/1906 |
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