A Novel Fast Photothermal Therapy Using Hot Spots of Gold Nanorods for Malignant Melanoma Cells
In this paper, the plasmon resonance effects of gold nanorods was used to achieve rapid photothermal therapy for malignant melanoma cells (A375 cells). After incubation with A375 cells for 24 h, gold nanorods were taken up by the cells and gold nanorod clusters were formed naturally in the organelle...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-10-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/8/11/880 |
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| author | Yanhua Yao Nannan Zhang Xiao Liu Qiaofeng Dai Haiying Liu Zhongchao Wei Shaolong Tie Yinyin Li Haihua Fan Sheng Lan |
| author_facet | Yanhua Yao Nannan Zhang Xiao Liu Qiaofeng Dai Haiying Liu Zhongchao Wei Shaolong Tie Yinyin Li Haihua Fan Sheng Lan |
| author_sort | Yanhua Yao |
| collection | DOAJ |
| description | In this paper, the plasmon resonance effects of gold nanorods was used to achieve rapid photothermal therapy for malignant melanoma cells (A375 cells). After incubation with A375 cells for 24 h, gold nanorods were taken up by the cells and gold nanorod clusters were formed naturally in the organelles of A375 cells. After analyzing the angle and space between the nanorods in clusters, a series of numerical simulations were performed and the results show that the plasmon resonance coupling between the gold nanorods can lead to a field enhancement of up to 60 times. Such high energy localization causes the temperature around the nanorods to rise rapidly and induce cell death. In this treatment, a laser as low as 9.3 mW was used to irradiate a single cell for 20 s and the cell died two h later. The cell death time can also be controlled by changing the power of laser which is focused on the cells. The advantage of this therapy is low laser treatment power, short treatment time, and small treatment range. As a result, the damage of the normal tissue by the photothermal effect can be greatly avoided. |
| first_indexed | 2024-12-10T06:51:49Z |
| format | Article |
| id | doaj.art-99ced176e8494585b24a997a6f7ebbf2 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-12-10T06:51:49Z |
| publishDate | 2018-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-99ced176e8494585b24a997a6f7ebbf22022-12-22T01:58:32ZengMDPI AGNanomaterials2079-49912018-10-0181188010.3390/nano8110880nano8110880A Novel Fast Photothermal Therapy Using Hot Spots of Gold Nanorods for Malignant Melanoma CellsYanhua Yao0Nannan Zhang1Xiao Liu2Qiaofeng Dai3Haiying Liu4Zhongchao Wei5Shaolong Tie6Yinyin Li7Haihua Fan8Sheng Lan9Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou 510006, ChinaGuangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou 510006, ChinaGuangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou 510006, ChinaGuangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou 510006, ChinaGuangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou 510006, ChinaGuangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou 510006, ChinaSchool of Chemistry and Environment, South China Normal University, Guangzhou 510006, ChinaSchool of Life Sciences, Sun Yat-Sen University, State Key Lab for Biocontrol, Guangzhou 510275, ChinaGuangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou 510006, ChinaGuangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou 510006, ChinaIn this paper, the plasmon resonance effects of gold nanorods was used to achieve rapid photothermal therapy for malignant melanoma cells (A375 cells). After incubation with A375 cells for 24 h, gold nanorods were taken up by the cells and gold nanorod clusters were formed naturally in the organelles of A375 cells. After analyzing the angle and space between the nanorods in clusters, a series of numerical simulations were performed and the results show that the plasmon resonance coupling between the gold nanorods can lead to a field enhancement of up to 60 times. Such high energy localization causes the temperature around the nanorods to rise rapidly and induce cell death. In this treatment, a laser as low as 9.3 mW was used to irradiate a single cell for 20 s and the cell died two h later. The cell death time can also be controlled by changing the power of laser which is focused on the cells. The advantage of this therapy is low laser treatment power, short treatment time, and small treatment range. As a result, the damage of the normal tissue by the photothermal effect can be greatly avoided.https://www.mdpi.com/2079-4991/8/11/880gold nanorodsA375 cellsplasmonic couplingphotothermal therapyhot spot |
| spellingShingle | Yanhua Yao Nannan Zhang Xiao Liu Qiaofeng Dai Haiying Liu Zhongchao Wei Shaolong Tie Yinyin Li Haihua Fan Sheng Lan A Novel Fast Photothermal Therapy Using Hot Spots of Gold Nanorods for Malignant Melanoma Cells Nanomaterials gold nanorods A375 cells plasmonic coupling photothermal therapy hot spot |
| title | A Novel Fast Photothermal Therapy Using Hot Spots of Gold Nanorods for Malignant Melanoma Cells |
| title_full | A Novel Fast Photothermal Therapy Using Hot Spots of Gold Nanorods for Malignant Melanoma Cells |
| title_fullStr | A Novel Fast Photothermal Therapy Using Hot Spots of Gold Nanorods for Malignant Melanoma Cells |
| title_full_unstemmed | A Novel Fast Photothermal Therapy Using Hot Spots of Gold Nanorods for Malignant Melanoma Cells |
| title_short | A Novel Fast Photothermal Therapy Using Hot Spots of Gold Nanorods for Malignant Melanoma Cells |
| title_sort | novel fast photothermal therapy using hot spots of gold nanorods for malignant melanoma cells |
| topic | gold nanorods A375 cells plasmonic coupling photothermal therapy hot spot |
| url | https://www.mdpi.com/2079-4991/8/11/880 |
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