Comorbid Mental Disorders and 6-Month Symptomatic and Functioning Outcomes in Chinese University Students at Clinical High Risk for Psychosis
BackgroundHigh rates of non-psychotic psychopathological symptoms have been observed in clinical population at clinical high risk (CHR) for psychosis. These comorbid disorders affected the baseline functional level of CHR patients. However, little is known about the comorbid mental disorder in CHR i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-10-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00209/full |
| _version_ | 1819264383502516224 |
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| author | Jingyu Shi Jingyu Shi Lu Wang Yuhong Yao Na Su Chenyu Zhan Ziyu Mao Xudong Zhao Xudong Zhao |
| author_facet | Jingyu Shi Jingyu Shi Lu Wang Yuhong Yao Na Su Chenyu Zhan Ziyu Mao Xudong Zhao Xudong Zhao |
| author_sort | Jingyu Shi |
| collection | DOAJ |
| description | BackgroundHigh rates of non-psychotic psychopathological symptoms have been observed in clinical population at clinical high risk (CHR) for psychosis. These comorbid disorders affected the baseline functional level of CHR patients. However, little is known about the comorbid mental disorder in CHR individuals in non-clinical adolescent population. This study aimed to investigate the comorbid mental disorder in non-clinical CHR adolescents and the impact on attenuated psychosis symptoms (APS) as well as clinical outcome.MethodsThe sample consisted of 32 CHR students, who were screened from 2,800 university students. CHR status was evaluated with the Structured Interview of Prodromal Syndromes, comorbid mental disorder diagnoses with the International Neuropsychiatric Interview.ResultsIn the CHR sample, 46.9% was found at least one non-psychotic comorbid mental disorder. The CHR participants presenting comorbid mental disorder had significantly more severity of APS than those without comorbid mental disorders, and the remission rate at 6-month follow-up is significantly higher in the individuals without comorbid mental disorders at baseline.ConclusionIn the non-clinical sample of individuals at CHR, non-psychotic comorbid mental disorders are common and anxiety disorder is most frequent. Copresence of anxiety and/or depression is related to higher level of attenuated psychotic symptoms and unfavorable clinical outcome at 6-month follow-up. Assessment and intervention in anxiety and depression for non-clinical CHR adolescents are suggested. |
| first_indexed | 2024-12-23T20:28:37Z |
| format | Article |
| id | doaj.art-99cf05390080496fbcbd3669b7b54402 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-23T20:28:37Z |
| publishDate | 2017-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-99cf05390080496fbcbd3669b7b544022022-12-21T17:32:19ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402017-10-01810.3389/fpsyt.2017.00209289673Comorbid Mental Disorders and 6-Month Symptomatic and Functioning Outcomes in Chinese University Students at Clinical High Risk for PsychosisJingyu Shi0Jingyu Shi1Lu Wang2Yuhong Yao3Na Su4Chenyu Zhan5Ziyu Mao6Xudong Zhao7Xudong Zhao8East Hospital, Tongji University School of Medicine, Shanghai, ChinaTongji University School of Medicine, Shanghai, ChinaEast Hospital, Tongji University School of Medicine, Shanghai, ChinaStudents Counseling Center, Tongji University, Shanghai, ChinaTongji University School of Medicine, Shanghai, ChinaEast Hospital, Tongji University School of Medicine, Shanghai, ChinaEast Hospital, Tongji University School of Medicine, Shanghai, ChinaEast Hospital, Tongji University School of Medicine, Shanghai, ChinaTongji University School of Medicine, Shanghai, ChinaBackgroundHigh rates of non-psychotic psychopathological symptoms have been observed in clinical population at clinical high risk (CHR) for psychosis. These comorbid disorders affected the baseline functional level of CHR patients. However, little is known about the comorbid mental disorder in CHR individuals in non-clinical adolescent population. This study aimed to investigate the comorbid mental disorder in non-clinical CHR adolescents and the impact on attenuated psychosis symptoms (APS) as well as clinical outcome.MethodsThe sample consisted of 32 CHR students, who were screened from 2,800 university students. CHR status was evaluated with the Structured Interview of Prodromal Syndromes, comorbid mental disorder diagnoses with the International Neuropsychiatric Interview.ResultsIn the CHR sample, 46.9% was found at least one non-psychotic comorbid mental disorder. The CHR participants presenting comorbid mental disorder had significantly more severity of APS than those without comorbid mental disorders, and the remission rate at 6-month follow-up is significantly higher in the individuals without comorbid mental disorders at baseline.ConclusionIn the non-clinical sample of individuals at CHR, non-psychotic comorbid mental disorders are common and anxiety disorder is most frequent. Copresence of anxiety and/or depression is related to higher level of attenuated psychotic symptoms and unfavorable clinical outcome at 6-month follow-up. Assessment and intervention in anxiety and depression for non-clinical CHR adolescents are suggested.http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00209/fullclinical high riskpsychosisdepressionanxietyuniversity studentslongitudinal |
| spellingShingle | Jingyu Shi Jingyu Shi Lu Wang Yuhong Yao Na Su Chenyu Zhan Ziyu Mao Xudong Zhao Xudong Zhao Comorbid Mental Disorders and 6-Month Symptomatic and Functioning Outcomes in Chinese University Students at Clinical High Risk for Psychosis Frontiers in Psychiatry clinical high risk psychosis depression anxiety university students longitudinal |
| title | Comorbid Mental Disorders and 6-Month Symptomatic and Functioning Outcomes in Chinese University Students at Clinical High Risk for Psychosis |
| title_full | Comorbid Mental Disorders and 6-Month Symptomatic and Functioning Outcomes in Chinese University Students at Clinical High Risk for Psychosis |
| title_fullStr | Comorbid Mental Disorders and 6-Month Symptomatic and Functioning Outcomes in Chinese University Students at Clinical High Risk for Psychosis |
| title_full_unstemmed | Comorbid Mental Disorders and 6-Month Symptomatic and Functioning Outcomes in Chinese University Students at Clinical High Risk for Psychosis |
| title_short | Comorbid Mental Disorders and 6-Month Symptomatic and Functioning Outcomes in Chinese University Students at Clinical High Risk for Psychosis |
| title_sort | comorbid mental disorders and 6 month symptomatic and functioning outcomes in chinese university students at clinical high risk for psychosis |
| topic | clinical high risk psychosis depression anxiety university students longitudinal |
| url | http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00209/full |
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