State-of-the-Art and Future Directions in Organ Regeneration with Mesenchymal Stem Cells and Derived Products during Dynamic Liver Preservation
Transplantation is currently the treatment of choice for end-stage liver diseases but is burdened by the shortage of donor organs. Livers from so-called extended-criteria donors represent a valid option to overcome organ shortage, but they are at risk for severe post-operative complications, especia...
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| Materyal Türü: | Makale |
| Dil: | English |
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MDPI AG
2022-12-01
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| Seri Bilgileri: | Medicina |
| Konular: | |
| Online Erişim: | https://www.mdpi.com/1648-9144/58/12/1826 |
| _version_ | 1827637908051329024 |
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| author | Nicola De Stefano Alberto Calleri Victor Navarro-Tableros Federica Rigo Damiano Patrono Renato Romagnoli |
| author_facet | Nicola De Stefano Alberto Calleri Victor Navarro-Tableros Federica Rigo Damiano Patrono Renato Romagnoli |
| author_sort | Nicola De Stefano |
| collection | DOAJ |
| description | Transplantation is currently the treatment of choice for end-stage liver diseases but is burdened by the shortage of donor organs. Livers from so-called extended-criteria donors represent a valid option to overcome organ shortage, but they are at risk for severe post-operative complications, especially when preserved with conventional static cold storage. Machine perfusion technology reduces ischemia-reperfusion injury and allows viability assessment of these organs, limiting their discard rate and improving short- and long-term outcomes after transplantation. Moreover, by keeping the graft metabolically active, the normothermic preservation technique guarantees a unique platform to administer regenerative therapies ex vivo. With their anti-inflammatory and immunomodulatory properties, mesenchymal stem cells are among the most promising sources of therapies for acute and chronic liver failure, but their routine clinical application is limited by several biosafety concerns. It is emerging that dynamic preservation and stem cell therapy may supplement each other if combined, as machine perfusion can be used to deliver stem cells to highly injured grafts, avoiding potential systemic side effects. The aim of this narrative review is to provide a comprehensive overview on liver preservation techniques and mesenchymal stem cell-based therapies, focusing on their application in liver graft reconditioning. |
| first_indexed | 2024-03-09T16:07:30Z |
| format | Article |
| id | doaj.art-99cf10eef20246c983222fbec3947935 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T16:07:30Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-99cf10eef20246c983222fbec39479352023-11-24T16:33:25ZengMDPI AGMedicina1010-660X1648-91442022-12-015812182610.3390/medicina58121826State-of-the-Art and Future Directions in Organ Regeneration with Mesenchymal Stem Cells and Derived Products during Dynamic Liver PreservationNicola De Stefano0Alberto Calleri1Victor Navarro-Tableros2Federica Rigo3Damiano Patrono4Renato Romagnoli5General Surgery 2U—Liver Transplant Unit, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, University of Torino, 10126 Turin, ItalyGastrohepatology Unit, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, University of Torino, 10126 Turin, Italy2i3T, Società per la Gestione dell’incubatore di Imprese e per il Trasferimento Tecnologico, University of Torino, 10126 Turin, ItalyGeneral Surgery 2U—Liver Transplant Unit, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, University of Torino, 10126 Turin, ItalyGeneral Surgery 2U—Liver Transplant Unit, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, University of Torino, 10126 Turin, ItalyGeneral Surgery 2U—Liver Transplant Unit, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, University of Torino, 10126 Turin, ItalyTransplantation is currently the treatment of choice for end-stage liver diseases but is burdened by the shortage of donor organs. Livers from so-called extended-criteria donors represent a valid option to overcome organ shortage, but they are at risk for severe post-operative complications, especially when preserved with conventional static cold storage. Machine perfusion technology reduces ischemia-reperfusion injury and allows viability assessment of these organs, limiting their discard rate and improving short- and long-term outcomes after transplantation. Moreover, by keeping the graft metabolically active, the normothermic preservation technique guarantees a unique platform to administer regenerative therapies ex vivo. With their anti-inflammatory and immunomodulatory properties, mesenchymal stem cells are among the most promising sources of therapies for acute and chronic liver failure, but their routine clinical application is limited by several biosafety concerns. It is emerging that dynamic preservation and stem cell therapy may supplement each other if combined, as machine perfusion can be used to deliver stem cells to highly injured grafts, avoiding potential systemic side effects. The aim of this narrative review is to provide a comprehensive overview on liver preservation techniques and mesenchymal stem cell-based therapies, focusing on their application in liver graft reconditioning.https://www.mdpi.com/1648-9144/58/12/1826liver machine perfusionliver regenerationmesenchymal stem cellsextracellular vesiclesliver transplantation |
| spellingShingle | Nicola De Stefano Alberto Calleri Victor Navarro-Tableros Federica Rigo Damiano Patrono Renato Romagnoli State-of-the-Art and Future Directions in Organ Regeneration with Mesenchymal Stem Cells and Derived Products during Dynamic Liver Preservation Medicina liver machine perfusion liver regeneration mesenchymal stem cells extracellular vesicles liver transplantation |
| title | State-of-the-Art and Future Directions in Organ Regeneration with Mesenchymal Stem Cells and Derived Products during Dynamic Liver Preservation |
| title_full | State-of-the-Art and Future Directions in Organ Regeneration with Mesenchymal Stem Cells and Derived Products during Dynamic Liver Preservation |
| title_fullStr | State-of-the-Art and Future Directions in Organ Regeneration with Mesenchymal Stem Cells and Derived Products during Dynamic Liver Preservation |
| title_full_unstemmed | State-of-the-Art and Future Directions in Organ Regeneration with Mesenchymal Stem Cells and Derived Products during Dynamic Liver Preservation |
| title_short | State-of-the-Art and Future Directions in Organ Regeneration with Mesenchymal Stem Cells and Derived Products during Dynamic Liver Preservation |
| title_sort | state of the art and future directions in organ regeneration with mesenchymal stem cells and derived products during dynamic liver preservation |
| topic | liver machine perfusion liver regeneration mesenchymal stem cells extracellular vesicles liver transplantation |
| url | https://www.mdpi.com/1648-9144/58/12/1826 |
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