WOMAN-PharmacoTXA trial: Study protocol for a randomised controlled trial to assess the pharmacokinetics and pharmacodynamics of intramuscular, intravenous and oral administration of tranexamic acid in women giving birth by caesarean section [version 1; peer review: 2 approved]

WOMAN-PharmacoTXA trial: Study protocol for a randomised controlled trial to assess the pharmacokinetics and pharmacodynamics of intramuscular, intravenous and oral administration of tranexamic acid in women giving birth by caesarean section [version 1; peer review: 2 approved]

Background: Intravenous tranexamic acid (TXA) within 3 hours of birth significantly reduces death due to bleeding in women with postpartum haemorrhage (PPH). Most PPH deaths occur in the first hours after giving birth and treatment delay decreases survival.  One barrier to rapid TXA treatment is the...

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Main Authors: Monica Arribas, Ian Roberts, Rizwana Chaudhri, Amber Geer, Danielle Prowse, Mwansa Ketty Lubeya, Aasia Kayani, Kiran Javaid, Stanislas Grassin-Delyle, Haleema Shakur-Still
Format: Article
Language:English
Published: Wellcome 2021-06-01
Series:Wellcome Open Research
Online Access:https://wellcomeopenresearch.org/articles/6-157/v1

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