DIAGNOSTIC VALUE OF pTAU AND NF-L LEVELS IN CEREBROSPINAL FLUID AND PLASMA IN PATIENTS WITH TRAUMATIC BRAIN INJURY
Severe traumatic brain injury (TBI) is among the leading causes of death worldwide, and survivors often suffer permanent cognitive and neurological impairment. Early diagnosis and treatment can greatly improve outcomes and recovery. The purpose of this study is to investigate the diagnostic value of...
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| Format: | Article |
| Language: | English |
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Union of Scientists - Stara Zagora
2024-04-01
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| Series: | Science & Research |
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| Online Access: |
http://www.sandtr.org/download.php?id=150
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| _version_ | 1827281095360512000 |
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| author | Stela Yancheva Svetlozar Spasov Georgi Pavlov Iliya Bivolarski Valentin Dichev Maria Kazakova Ivan Tsranchev |
| author_facet | Stela Yancheva Svetlozar Spasov Georgi Pavlov Iliya Bivolarski Valentin Dichev Maria Kazakova Ivan Tsranchev |
| author_sort | Stela Yancheva |
| collection | DOAJ |
| description | Severe traumatic brain injury (TBI) is among the leading causes of death worldwide, and survivors often suffer permanent cognitive and neurological impairment. Early diagnosis and treatment can greatly improve outcomes and recovery.
The purpose of this study is to investigate the diagnostic value of the biochemical markers pTau and NF-L in the early diagnosis of TBI in patients by analysing their concentration in cerebrospinal fluid and blood plasma.
The study includes 20 cases of patients who suffered severe TBI. Within 24 hours of the injury, cerebrospinal fluid and plasma were collected and compared to identical samples obtained from a control group of 11 non-traumatic cadavers.
The results from the present study show significant rise in cerebrospinal pTau and plasma NF-L levels in the control group, and insignificant rise of the levels of plasma pTau in TBI patients. In conclusion, the investigated molecules pTau and NF-L are not reliable for early diagnosis and monitoring of TBI. |
| first_indexed | 2024-04-24T08:53:28Z |
| format | Article |
| id | doaj.art-99d0cead98a24fa99e7d22ce0cea2f99 |
| institution | Directory Open Access Journal |
| issn | 2535-0765 |
| language | English |
| last_indexed | 2024-04-24T08:53:28Z |
| publishDate | 2024-04-01 |
| publisher | Union of Scientists - Stara Zagora |
| record_format | Article |
| series | Science & Research |
| spelling | doaj.art-99d0cead98a24fa99e7d22ce0cea2f992024-04-16T09:15:37ZengUnion of Scientists - Stara ZagoraScience & Research2535-07652024-04-01150DIAGNOSTIC VALUE OF pTAU AND NF-L LEVELS IN CEREBROSPINAL FLUID AND PLASMA IN PATIENTS WITH TRAUMATIC BRAIN INJURYStela YanchevaSvetlozar SpasovGeorgi PavlovIliya BivolarskiValentin DichevMaria KazakovaIvan TsranchevSevere traumatic brain injury (TBI) is among the leading causes of death worldwide, and survivors often suffer permanent cognitive and neurological impairment. Early diagnosis and treatment can greatly improve outcomes and recovery. The purpose of this study is to investigate the diagnostic value of the biochemical markers pTau and NF-L in the early diagnosis of TBI in patients by analysing their concentration in cerebrospinal fluid and blood plasma. The study includes 20 cases of patients who suffered severe TBI. Within 24 hours of the injury, cerebrospinal fluid and plasma were collected and compared to identical samples obtained from a control group of 11 non-traumatic cadavers. The results from the present study show significant rise in cerebrospinal pTau and plasma NF-L levels in the control group, and insignificant rise of the levels of plasma pTau in TBI patients. In conclusion, the investigated molecules pTau and NF-L are not reliable for early diagnosis and monitoring of TBI. http://www.sandtr.org/download.php?id=150 biomarkersbrain injurytaunftbi |
| spellingShingle | Stela Yancheva Svetlozar Spasov Georgi Pavlov Iliya Bivolarski Valentin Dichev Maria Kazakova Ivan Tsranchev DIAGNOSTIC VALUE OF pTAU AND NF-L LEVELS IN CEREBROSPINAL FLUID AND PLASMA IN PATIENTS WITH TRAUMATIC BRAIN INJURY Science & Research biomarkers brain injury tau nf tbi |
| title | DIAGNOSTIC VALUE OF pTAU AND NF-L LEVELS IN CEREBROSPINAL FLUID AND PLASMA IN PATIENTS WITH TRAUMATIC BRAIN INJURY |
| title_full | DIAGNOSTIC VALUE OF pTAU AND NF-L LEVELS IN CEREBROSPINAL FLUID AND PLASMA IN PATIENTS WITH TRAUMATIC BRAIN INJURY |
| title_fullStr | DIAGNOSTIC VALUE OF pTAU AND NF-L LEVELS IN CEREBROSPINAL FLUID AND PLASMA IN PATIENTS WITH TRAUMATIC BRAIN INJURY |
| title_full_unstemmed | DIAGNOSTIC VALUE OF pTAU AND NF-L LEVELS IN CEREBROSPINAL FLUID AND PLASMA IN PATIENTS WITH TRAUMATIC BRAIN INJURY |
| title_short | DIAGNOSTIC VALUE OF pTAU AND NF-L LEVELS IN CEREBROSPINAL FLUID AND PLASMA IN PATIENTS WITH TRAUMATIC BRAIN INJURY |
| title_sort | diagnostic value of ptau and nf l levels in cerebrospinal fluid and plasma in patients with traumatic brain injury |
| topic | biomarkers brain injury tau nf tbi |
| url |
http://www.sandtr.org/download.php?id=150
|
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