Anticancer Activity, Reduction Mechanism and G-Quadruplex DNA Binding of a Redox-Activated Platinum(IV)–Salphen Complex

Anticancer Activity, Reduction Mechanism and G-Quadruplex DNA Binding of a Redox-Activated Platinum(IV)–Salphen Complex

Aiming at reducing the unselective cytotoxicity of Pt(II) chemotherapeutics, a great deal of effort has been concentrated into the design of metal-containing drugs with different anticancer mechanisms of action. Inert Pt(IV) prodrugs have been proposed to be a valid alternative as they are activated...

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Bibliographic Details
Main Authors: Vincenzo Vigna, Stefano Scoditti, Angelo Spinello, Gloria Mazzone, Emilia Sicilia
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
Pt(IV) complexes
G-quadruplex
DFT
MD
Online Access:https://www.mdpi.com/1422-0067/23/24/15579

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