AMPA Receptor Trafficking for Postsynaptic Potentiation
Long-term potentiation (LTP) of excitatory synaptic strength, which has long been considered a synaptic correlate for learning and memory, requires a fast recruitment of additional α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors (AMPARs) to the postsynaptic sites. As cell biologica...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-10-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2018.00361/full |
| _version_ | 1818949965621231616 |
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| author | Mikyoung Park Mikyoung Park |
| author_facet | Mikyoung Park Mikyoung Park |
| author_sort | Mikyoung Park |
| collection | DOAJ |
| description | Long-term potentiation (LTP) of excitatory synaptic strength, which has long been considered a synaptic correlate for learning and memory, requires a fast recruitment of additional α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors (AMPARs) to the postsynaptic sites. As cell biological concepts have been applied to the field and genetic manipulation and microscopic imaging technologies have been advanced, visualization of the trafficking of AMPARs to synapses for LTP has been investigated intensively over the last decade. Recycling endosomes have been reported as intracellular storage organelles to supply AMPARs for LTP through the endocytic recycling pathway. In addition, exocytic domains in the spine plasma membrane, where AMPARs are inserted from the intracellular compartment, and nanodomains, where diffusing AMPARs are trapped and immobilized inside synapses for LTP, have been described. Furthermore, cell surface lateral diffusion of AMPARs from extrasynaptic to synaptic sites has been reported as a key step for AMPAR location to the synaptic sites for LTP. This review article will discuss recent findings and views on the reservoir(s) of AMPARs and their trafficking for LTP expression by focusing on the exocytosis and lateral diffusion of AMPARs, and provide some future directions that need to be addressed in the field of LTP. |
| first_indexed | 2024-12-20T09:11:05Z |
| format | Article |
| id | doaj.art-99d532c9cbdc47ed83c40d089357f0ee |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-20T09:11:05Z |
| publishDate | 2018-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-99d532c9cbdc47ed83c40d089357f0ee2022-12-21T19:45:33ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022018-10-011210.3389/fncel.2018.00361416111AMPA Receptor Trafficking for Postsynaptic PotentiationMikyoung Park0Mikyoung Park1Center for Functional Connectomics, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, South KoreaDepartment of Neuroscience, Korea University of Science and Technology, Daejeon, South KoreaLong-term potentiation (LTP) of excitatory synaptic strength, which has long been considered a synaptic correlate for learning and memory, requires a fast recruitment of additional α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors (AMPARs) to the postsynaptic sites. As cell biological concepts have been applied to the field and genetic manipulation and microscopic imaging technologies have been advanced, visualization of the trafficking of AMPARs to synapses for LTP has been investigated intensively over the last decade. Recycling endosomes have been reported as intracellular storage organelles to supply AMPARs for LTP through the endocytic recycling pathway. In addition, exocytic domains in the spine plasma membrane, where AMPARs are inserted from the intracellular compartment, and nanodomains, where diffusing AMPARs are trapped and immobilized inside synapses for LTP, have been described. Furthermore, cell surface lateral diffusion of AMPARs from extrasynaptic to synaptic sites has been reported as a key step for AMPAR location to the synaptic sites for LTP. This review article will discuss recent findings and views on the reservoir(s) of AMPARs and their trafficking for LTP expression by focusing on the exocytosis and lateral diffusion of AMPARs, and provide some future directions that need to be addressed in the field of LTP.https://www.frontiersin.org/article/10.3389/fncel.2018.00361/fullAMPA receptorslong-term potentiationpostsynapseexocytosislateral diffusion |
| spellingShingle | Mikyoung Park Mikyoung Park AMPA Receptor Trafficking for Postsynaptic Potentiation Frontiers in Cellular Neuroscience AMPA receptors long-term potentiation postsynapse exocytosis lateral diffusion |
| title | AMPA Receptor Trafficking for Postsynaptic Potentiation |
| title_full | AMPA Receptor Trafficking for Postsynaptic Potentiation |
| title_fullStr | AMPA Receptor Trafficking for Postsynaptic Potentiation |
| title_full_unstemmed | AMPA Receptor Trafficking for Postsynaptic Potentiation |
| title_short | AMPA Receptor Trafficking for Postsynaptic Potentiation |
| title_sort | ampa receptor trafficking for postsynaptic potentiation |
| topic | AMPA receptors long-term potentiation postsynapse exocytosis lateral diffusion |
| url | https://www.frontiersin.org/article/10.3389/fncel.2018.00361/full |
| work_keys_str_mv | AT mikyoungpark ampareceptortraffickingforpostsynapticpotentiation AT mikyoungpark ampareceptortraffickingforpostsynapticpotentiation |