The prevalence of cardiorenal anemia syndrome among patients with heart failure and its association with all-cause hospitalizations: a retrospective single-center study from the Middle East
Background and aimLittle is known about the burden of cardiorenal syndrome (CRS) and cardiorenal anemia syndrome (CRAS) in the Middle East Region. Furthermore, whether the occurrence rates of CRAS differ across heart failure (HF) phenotypes is not widely investigated. We aimed to examine the prevale...
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| Format: | Article |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1244275/full |
| _version_ | 1797688027656486912 |
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| author | Yosef Manla Yosef Manla Obada Kholoki Feras Bader Oshin Kanwar Emna Abidi Emna Abidi Wasim S. El Nekidy Fadi Hijazi Nizar Attallah |
| author_facet | Yosef Manla Yosef Manla Obada Kholoki Feras Bader Oshin Kanwar Emna Abidi Emna Abidi Wasim S. El Nekidy Fadi Hijazi Nizar Attallah |
| author_sort | Yosef Manla |
| collection | DOAJ |
| description | Background and aimLittle is known about the burden of cardiorenal syndrome (CRS) and cardiorenal anemia syndrome (CRAS) in the Middle East Region. Furthermore, whether the occurrence rates of CRAS differ across heart failure (HF) phenotypes is not widely investigated. We aimed to examine the prevalence of CRS and CRAS in patients with HF, compare characteristics of patients with CRAS-HFrEF vs. CRAS-HFpEF, and investigate anemia association with 1-year all-cause hospitalizations.MethodsHF patients who visited a multidisciplinary HF clinic at a single center between 10-2015 and 06-2022 (n = 968) were retrospectively included. Differences in rates of CRAS prevalence, and patients’ characteristics of those with CRAS-HFrEF vs. CRAS-HFpEF were determined using appropriate testing methods. Generalized estimating equation (GEE) models were used to determine if anemia was associated with higher rates of hospitalization.ResultsCRS was prevalent in 34.4% of subjects, while 25.3% had CRAS. CRAS prevalence rates among patients with HFpEF vs. HFrEF were comparable (27.2% vs. 24.2%, p = 0.3). Compared to patients with HFrEF-CRAS, those with HFpEF-CRAS were more likely females (p < 0.001), had a higher burden of hypertension (p = 0.01), and lower hemoglobin (p = 0.02). In an adjusted GEE model, anemia was associated with an average increase of 1.8 admissions in CRS patients (p = 0.015).ConclusionIn patients with HF, 1 in 3 patients presented with CRS, and 1 in 4 patients had CRAS. The prevalence of CRAS was comparable among those HFpEF and HFrEF. Anemia was associated with an increased rate of 1-year all-cause hospitalization in CRS patients. |
| first_indexed | 2024-03-12T01:26:27Z |
| format | Article |
| id | doaj.art-99d58d681d6f4314ad236c3da94f9a23 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-12T01:26:27Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-99d58d681d6f4314ad236c3da94f9a232023-09-12T18:15:37ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-09-011010.3389/fcvm.2023.12442751244275The prevalence of cardiorenal anemia syndrome among patients with heart failure and its association with all-cause hospitalizations: a retrospective single-center study from the Middle EastYosef Manla0Yosef Manla1Obada Kholoki2Feras Bader3Oshin Kanwar4Emna Abidi5Emna Abidi6Wasim S. El Nekidy7Fadi Hijazi8Nizar Attallah9Department of Cardiology, Heart, Vascular, and Thoracic Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab EmiratesResearch Department, Academic Office, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab EmiratesDepartment of Cardiology, Heart, Vascular, and Thoracic Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab EmiratesDepartment of Cardiology, Heart, Vascular, and Thoracic Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab EmiratesResearch Department, Academic Office, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab EmiratesResearch Department, Academic Office, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab EmiratesDepartment of Pharmacy, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab EmiratesDepartment of Pharmacy, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab EmiratesDepartment of Nephrology, Medical Subspecialties Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab EmiratesDepartment of Nephrology, Medical Subspecialties Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab EmiratesBackground and aimLittle is known about the burden of cardiorenal syndrome (CRS) and cardiorenal anemia syndrome (CRAS) in the Middle East Region. Furthermore, whether the occurrence rates of CRAS differ across heart failure (HF) phenotypes is not widely investigated. We aimed to examine the prevalence of CRS and CRAS in patients with HF, compare characteristics of patients with CRAS-HFrEF vs. CRAS-HFpEF, and investigate anemia association with 1-year all-cause hospitalizations.MethodsHF patients who visited a multidisciplinary HF clinic at a single center between 10-2015 and 06-2022 (n = 968) were retrospectively included. Differences in rates of CRAS prevalence, and patients’ characteristics of those with CRAS-HFrEF vs. CRAS-HFpEF were determined using appropriate testing methods. Generalized estimating equation (GEE) models were used to determine if anemia was associated with higher rates of hospitalization.ResultsCRS was prevalent in 34.4% of subjects, while 25.3% had CRAS. CRAS prevalence rates among patients with HFpEF vs. HFrEF were comparable (27.2% vs. 24.2%, p = 0.3). Compared to patients with HFrEF-CRAS, those with HFpEF-CRAS were more likely females (p < 0.001), had a higher burden of hypertension (p = 0.01), and lower hemoglobin (p = 0.02). In an adjusted GEE model, anemia was associated with an average increase of 1.8 admissions in CRS patients (p = 0.015).ConclusionIn patients with HF, 1 in 3 patients presented with CRS, and 1 in 4 patients had CRAS. The prevalence of CRAS was comparable among those HFpEF and HFrEF. Anemia was associated with an increased rate of 1-year all-cause hospitalization in CRS patients.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1244275/fullcardiorenal anemia syndromecardiorenal syndromeheart failureMiddle Eastchronic kidney disease |
| spellingShingle | Yosef Manla Yosef Manla Obada Kholoki Feras Bader Oshin Kanwar Emna Abidi Emna Abidi Wasim S. El Nekidy Fadi Hijazi Nizar Attallah The prevalence of cardiorenal anemia syndrome among patients with heart failure and its association with all-cause hospitalizations: a retrospective single-center study from the Middle East Frontiers in Cardiovascular Medicine cardiorenal anemia syndrome cardiorenal syndrome heart failure Middle East chronic kidney disease |
| title | The prevalence of cardiorenal anemia syndrome among patients with heart failure and its association with all-cause hospitalizations: a retrospective single-center study from the Middle East |
| title_full | The prevalence of cardiorenal anemia syndrome among patients with heart failure and its association with all-cause hospitalizations: a retrospective single-center study from the Middle East |
| title_fullStr | The prevalence of cardiorenal anemia syndrome among patients with heart failure and its association with all-cause hospitalizations: a retrospective single-center study from the Middle East |
| title_full_unstemmed | The prevalence of cardiorenal anemia syndrome among patients with heart failure and its association with all-cause hospitalizations: a retrospective single-center study from the Middle East |
| title_short | The prevalence of cardiorenal anemia syndrome among patients with heart failure and its association with all-cause hospitalizations: a retrospective single-center study from the Middle East |
| title_sort | prevalence of cardiorenal anemia syndrome among patients with heart failure and its association with all cause hospitalizations a retrospective single center study from the middle east |
| topic | cardiorenal anemia syndrome cardiorenal syndrome heart failure Middle East chronic kidney disease |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1244275/full |
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