Factors Enhancing Drug-induced Hepatotoxicity among Thai Patients with TB
Introduction: Drug-Induced Hepatotoxicity (DIH) is usually found in patients with Tuberculosis (TB) who have received the standard anti-TB treatment due to the specific drugs in the standard regimen as well as other factors. Hepatotoxicity is the main cause of drug discontinuation and influences...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2020-09-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/14008/44816_CE[Ra1]_F(SHU)_PF1(AKA_KM)_PFA(AKA_KM)_PN(SL).pdf |
| Summary: | Introduction: Drug-Induced Hepatotoxicity (DIH) is usually
found in patients with Tuberculosis (TB) who have received
the standard anti-TB treatment due to the specific drugs in
the standard regimen as well as other factors. Hepatotoxicity
is the main cause of drug discontinuation and influences drug
resistance and fulminant hepatitis in patients with TB.
Aim: This study aims to assess the factors enhancing DIH in
patients with TB who received the standard anti-TB regiment in
Phichit Hospital, Thailand.
Materials and Methods: A retrospective study was used to
examine factors that enhanced DIH in 327 new patients with TB
who received the standard anti-TB treatment at the TB-clinic in
Phichit Hospital from October 1st, 2016 to September 30th, 2018.
Data was collected from medical and laboratory records at the
TB clinic. The univariate and multivariate logistic regression
were used to assess factors enhancing DIH in patients with TB,
reported using an Adjusted Odd Ratio (AOR) of 95% CI and a
p-value of <0.05.
Results: The results of this study confirmed that malnutrition was
positively associated with increased risk of DIH development
{AOR 4.40 (1.26 to 12.26), p=0.01}. In addition, an age of >60
years was associated with an increased risk of DIH development
{AOR 2.87 (95% CI 1.16 to 7.14), p=0.02}.
Conclusion: For TB patients, being over 60-year-old and
malnutrition are significant factors related to DIH. Therefore, the
new patients with TB should receive the screening for present
chronic liver disease, including AST and ALT whenever feasible,
and nutritional assessment should be done for elderly patients
before start of anti-TB treatment. |
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| ISSN: | 2249-782X 0973-709X |