JP2 Genotype of <i>Aggregatibacter actinomycetemcomitans</i> in Caucasian Patients: A Presentation of Two Cases
<i>Aggregatibacter actinomycetemcomitans</i> is a key pathogen that has been associated with periodontal disease. Its most important virulence factor is a leukotoxin capable of inactivating immune cells. The JP2 genotype of <i>Aggregatibacter actinomycetemcomitans </i>shows e...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-03-01
|
| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/9/3/178 |
| _version_ | 1818037479031177216 |
|---|---|
| author | Alexandra Stähli Anton Sculean Sigrun Eick |
| author_facet | Alexandra Stähli Anton Sculean Sigrun Eick |
| author_sort | Alexandra Stähli |
| collection | DOAJ |
| description | <i>Aggregatibacter actinomycetemcomitans</i> is a key pathogen that has been associated with periodontal disease. Its most important virulence factor is a leukotoxin capable of inactivating immune cells. The JP2 genotype of <i>Aggregatibacter actinomycetemcomitans </i>shows enhanced leukotoxic activity<i> </i>and<i> </i>is mostly present in individuals of North and West African origin with severe periodontitis. In this paper, two cases of Caucasians diagnosed with the JP2 genotype are presented. A 50-year-old female patient had three approximal sites with ≥ 6 mm clinical attachment loss (CAL) and eight sites with probing depth (PD) ≥ 5 mm. Microbiological diagnostics revealed <i>A. actinomycetemcomitans </i>JP2 genotype, but not <i>Porphyromonas gingivalis</i>. This JP2 genotype was highly leukotoxic to monocytic cells. The second case was a 55-year-old female patient with CAL of > 5 mm at all molars and PD of up to 12 mm. <i>A. actinomycetemcomitans </i>JP2 was identified, but not <i>P. gingivalis</i>. Her husband originated from North-Africa. In him, no <i>A. actinomycetemcomitans</i> was detected, but their 17-year-old daughter was diagnosed with periodontitis and was found to be positive for the JP2 genotype. Both patients were successfully treated with adjunctive antibiotics and the JP2 genotype was eliminated. In summary, here, the microbiological diagnosis was key for the treatment with adjunctive antibiotics. |
| first_indexed | 2024-12-10T07:27:29Z |
| format | Article |
| id | doaj.art-99d7e6684ecd453ba00ed6d1ccf1f53e |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-12-10T07:27:29Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-99d7e6684ecd453ba00ed6d1ccf1f53e2022-12-22T01:57:39ZengMDPI AGPathogens2076-08172020-03-019317810.3390/pathogens9030178pathogens9030178JP2 Genotype of <i>Aggregatibacter actinomycetemcomitans</i> in Caucasian Patients: A Presentation of Two CasesAlexandra Stähli0Anton Sculean1Sigrun Eick2Department of Periodontology, School of Dental Medicine, University of Bern, Freiburgstrasse 7, Bern 3010, SwitzerlandDepartment of Periodontology, School of Dental Medicine, University of Bern, Freiburgstrasse 7, Bern 3010, SwitzerlandDepartment of Periodontology, School of Dental Medicine, University of Bern, Freiburgstrasse 7, Bern 3010, Switzerland<i>Aggregatibacter actinomycetemcomitans</i> is a key pathogen that has been associated with periodontal disease. Its most important virulence factor is a leukotoxin capable of inactivating immune cells. The JP2 genotype of <i>Aggregatibacter actinomycetemcomitans </i>shows enhanced leukotoxic activity<i> </i>and<i> </i>is mostly present in individuals of North and West African origin with severe periodontitis. In this paper, two cases of Caucasians diagnosed with the JP2 genotype are presented. A 50-year-old female patient had three approximal sites with ≥ 6 mm clinical attachment loss (CAL) and eight sites with probing depth (PD) ≥ 5 mm. Microbiological diagnostics revealed <i>A. actinomycetemcomitans </i>JP2 genotype, but not <i>Porphyromonas gingivalis</i>. This JP2 genotype was highly leukotoxic to monocytic cells. The second case was a 55-year-old female patient with CAL of > 5 mm at all molars and PD of up to 12 mm. <i>A. actinomycetemcomitans </i>JP2 was identified, but not <i>P. gingivalis</i>. Her husband originated from North-Africa. In him, no <i>A. actinomycetemcomitans</i> was detected, but their 17-year-old daughter was diagnosed with periodontitis and was found to be positive for the JP2 genotype. Both patients were successfully treated with adjunctive antibiotics and the JP2 genotype was eliminated. In summary, here, the microbiological diagnosis was key for the treatment with adjunctive antibiotics.https://www.mdpi.com/2076-0817/9/3/178jp2 clone of <i>aggregatibacter actinomycetemcomitans</i>periodontitisjp2 in caucasianmicrobiological diagnosisadjunctive antibiotics |
| spellingShingle | Alexandra Stähli Anton Sculean Sigrun Eick JP2 Genotype of <i>Aggregatibacter actinomycetemcomitans</i> in Caucasian Patients: A Presentation of Two Cases Pathogens jp2 clone of <i>aggregatibacter actinomycetemcomitans</i> periodontitis jp2 in caucasian microbiological diagnosis adjunctive antibiotics |
| title | JP2 Genotype of <i>Aggregatibacter actinomycetemcomitans</i> in Caucasian Patients: A Presentation of Two Cases |
| title_full | JP2 Genotype of <i>Aggregatibacter actinomycetemcomitans</i> in Caucasian Patients: A Presentation of Two Cases |
| title_fullStr | JP2 Genotype of <i>Aggregatibacter actinomycetemcomitans</i> in Caucasian Patients: A Presentation of Two Cases |
| title_full_unstemmed | JP2 Genotype of <i>Aggregatibacter actinomycetemcomitans</i> in Caucasian Patients: A Presentation of Two Cases |
| title_short | JP2 Genotype of <i>Aggregatibacter actinomycetemcomitans</i> in Caucasian Patients: A Presentation of Two Cases |
| title_sort | jp2 genotype of i aggregatibacter actinomycetemcomitans i in caucasian patients a presentation of two cases |
| topic | jp2 clone of <i>aggregatibacter actinomycetemcomitans</i> periodontitis jp2 in caucasian microbiological diagnosis adjunctive antibiotics |
| url | https://www.mdpi.com/2076-0817/9/3/178 |
| work_keys_str_mv | AT alexandrastahli jp2genotypeofiaggregatibacteractinomycetemcomitansiincaucasianpatientsapresentationoftwocases AT antonsculean jp2genotypeofiaggregatibacteractinomycetemcomitansiincaucasianpatientsapresentationoftwocases AT sigruneick jp2genotypeofiaggregatibacteractinomycetemcomitansiincaucasianpatientsapresentationoftwocases |