Wound healing and anti-inflammatory effects of recombinant human angiogenin
New effective wound healing agents are a priority for modern clinical pharmacology. A promising approach would be to develop medicinal products that promote angiogenesis, which is a critical step in wound healing. The aim of the study was to evaluate the wound healing effect of a medicinal product b...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products»
2022-10-01
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| Series: | Биопрепараты: Профилактика, диагностика, лечение |
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| Online Access: | https://www.biopreparations.ru/jour/article/view/404 |
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| author | A. E. Gulyayev Z. T. Shulgau S. D. Sergazy N. V. Yurina A. M. Goryachkin S. S. Bogachev A. S. Proskurina |
| author_facet | A. E. Gulyayev Z. T. Shulgau S. D. Sergazy N. V. Yurina A. M. Goryachkin S. S. Bogachev A. S. Proskurina |
| author_sort | A. E. Gulyayev |
| collection | DOAJ |
| description | New effective wound healing agents are a priority for modern clinical pharmacology. A promising approach would be to develop medicinal products that promote angiogenesis, which is a critical step in wound healing. The aim of the study was to evaluate the wound healing effect of a medicinal product based on recombinant human angiogenin in gel form in various experimental models. Materials and methods: white outbred male rats were used as experimental ani mals. The study compared healing effects of a regenerating product containing recombinant human angiogenin (0.0025%) in gel form and a reference product in full-thickness excision, incision, and burn wound models. The healing effect of the test product in treating chronic wounds was assessed in a model of alloxan-induced diabetes mellitus. The anti-inflammatory effect of the test product containing recombinant human angiogenin was compared with that of another reference product in a model of adjuvant-induced arthritis. Results: according to the study, the test product based on recombinant human angiogenin exerts higher wound healing effect in treating excision, incision, and burn wounds than the reference product (Solcoseryl gel). Being applied, the test product intensifies tissue repair in chronic wounds in the model of alloxan-induced diabetes. The dissociation of necrotic tissues and the progression towards epithelialisation at wound edges are more rapid. The anti-inflammatory effect of the test product based on recombinant human angiogenin is comparable with that of the reference product (Diclofenac gel). Conclusions: the test product based on recombinant human angiogenin in gel form was found to have pronounced wound healing and anti-inflammatory effects comparable with those of reference products. |
| first_indexed | 2024-03-08T21:43:13Z |
| format | Article |
| id | doaj.art-99d8afe69a524d968a52c67901f1abe0 |
| institution | Directory Open Access Journal |
| issn | 2221-996X 2619-1156 |
| language | Russian |
| last_indexed | 2024-04-24T19:11:56Z |
| publishDate | 2022-10-01 |
| publisher | Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» |
| record_format | Article |
| series | Биопрепараты: Профилактика, диагностика, лечение |
| spelling | doaj.art-99d8afe69a524d968a52c67901f1abe02024-03-26T09:10:53ZrusMinistry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products»Биопрепараты: Профилактика, диагностика, лечение2221-996X2619-11562022-10-0122329330710.30895/2221-996X-2022-22-3-293-307287Wound healing and anti-inflammatory effects of recombinant human angiogeninA. E. Gulyayev0Z. T. Shulgau1S. D. Sergazy2N. V. Yurina3A. M. Goryachkin4S. S. Bogachev5A. S. Proskurina6National Center for BiotechnologyNational Center for BiotechnologyNational Center for Biotechnology; National Laboratory Astana, Nazarbayev UniversityRegional Center for High Medical TechnologiesNovosibirsk State Medical UniversityInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of SciencesInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of SciencesNew effective wound healing agents are a priority for modern clinical pharmacology. A promising approach would be to develop medicinal products that promote angiogenesis, which is a critical step in wound healing. The aim of the study was to evaluate the wound healing effect of a medicinal product based on recombinant human angiogenin in gel form in various experimental models. Materials and methods: white outbred male rats were used as experimental ani mals. The study compared healing effects of a regenerating product containing recombinant human angiogenin (0.0025%) in gel form and a reference product in full-thickness excision, incision, and burn wound models. The healing effect of the test product in treating chronic wounds was assessed in a model of alloxan-induced diabetes mellitus. The anti-inflammatory effect of the test product containing recombinant human angiogenin was compared with that of another reference product in a model of adjuvant-induced arthritis. Results: according to the study, the test product based on recombinant human angiogenin exerts higher wound healing effect in treating excision, incision, and burn wounds than the reference product (Solcoseryl gel). Being applied, the test product intensifies tissue repair in chronic wounds in the model of alloxan-induced diabetes. The dissociation of necrotic tissues and the progression towards epithelialisation at wound edges are more rapid. The anti-inflammatory effect of the test product based on recombinant human angiogenin is comparable with that of the reference product (Diclofenac gel). Conclusions: the test product based on recombinant human angiogenin in gel form was found to have pronounced wound healing and anti-inflammatory effects comparable with those of reference products.https://www.biopreparations.ru/jour/article/view/404excision woundincision woundburn woundalloxan-induced diabetes mellitusadjuvant-induced arthritisanti-inflammatory agentrecombinant human angiogenin |
| spellingShingle | A. E. Gulyayev Z. T. Shulgau S. D. Sergazy N. V. Yurina A. M. Goryachkin S. S. Bogachev A. S. Proskurina Wound healing and anti-inflammatory effects of recombinant human angiogenin Биопрепараты: Профилактика, диагностика, лечение excision wound incision wound burn wound alloxan-induced diabetes mellitus adjuvant-induced arthritis anti-inflammatory agent recombinant human angiogenin |
| title | Wound healing and anti-inflammatory effects of recombinant human angiogenin |
| title_full | Wound healing and anti-inflammatory effects of recombinant human angiogenin |
| title_fullStr | Wound healing and anti-inflammatory effects of recombinant human angiogenin |
| title_full_unstemmed | Wound healing and anti-inflammatory effects of recombinant human angiogenin |
| title_short | Wound healing and anti-inflammatory effects of recombinant human angiogenin |
| title_sort | wound healing and anti inflammatory effects of recombinant human angiogenin |
| topic | excision wound incision wound burn wound alloxan-induced diabetes mellitus adjuvant-induced arthritis anti-inflammatory agent recombinant human angiogenin |
| url | https://www.biopreparations.ru/jour/article/view/404 |
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