Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung

Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung

Abstract Background Aldehyde dehydrogenases (ALDHs) play a major role in detoxification of aldehydes. High expression of ALDHs is a marker for stem cells of many organs including the lungs. A common polymorphism in ALDH2 gene (ALDH2*2) results in inactivation of the enzyme and is associated with alc...

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Bibliographic Details
Main Authors: Aoi Kuroda, Ahmed E. Hegab, Gao Jingtao, Shuji Yamashita, Nobuyuki Hizawa, Tohru Sakamoto, Hideyasu Yamada, Satoshi Suzuki, Makoto Ishii, Ho Namkoong, Takanori Asakura, Mari Ozaki, Hiroyuki Yasuda, Junko Hamamoto, Shizuko Kagawa, Kenzo Soejima, Tomoko Betsuyaku
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Respiratory Research
Subjects:
ALDH2
Aldehyde
Epithelial cell
Basal cell
Club cell
Trachea
Online Access:http://link.springer.com/article/10.1186/s12931-017-0554-5

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