Simultaneous non-steroidal anti-inflammatory drug electrodetection on nitrogen doped carbon nanodots and nanosized cobalt phthallocyanine conjugate modified glassy carbon electrode
Nitrogen doped carbon nanodots (NDCNDs) and nanosized cobalt tetra aminophenoxy phthalocyanines (CoTAPhPcNPs) modified glassy carbon electrodes have been successfully used in the simultaneous detection of aspirin (ASA), ibuprofen (IBU) and indomethacin (INDO). Scanning electron microscopy (SEM), tra...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-11-01
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| Series: | Arabian Journal of Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535220303361 |
| _version_ | 1818302713454133248 |
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| author | Nyaradzai Dondo Munyaradzi Shumba Mambo Moyo Stephen Nyoni |
| author_facet | Nyaradzai Dondo Munyaradzi Shumba Mambo Moyo Stephen Nyoni |
| author_sort | Nyaradzai Dondo |
| collection | DOAJ |
| description | Nitrogen doped carbon nanodots (NDCNDs) and nanosized cobalt tetra aminophenoxy phthalocyanines (CoTAPhPcNPs) modified glassy carbon electrodes have been successfully used in the simultaneous detection of aspirin (ASA), ibuprofen (IBU) and indomethacin (INDO). Scanning electron microscopy (SEM), transmission electron microscopy (TEM), UV–Vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were used to probe the nature of the synthesized nanomaterials. Sequential deposition of the nanomaterials on the glassy carbon electrode yielded CoTAPhPcNPs-NDCNDs-GCE with remarkable electrocatalytic performance. Electro-oxidation of the drugs at the electrode surface was first order. This work demonstrates the synergic effect of the two nanomaterials towards simultaneous electrocatalytic detection of the drugs. Superior detection limits of ASA, IBU and INDO being 9.66 × 10−9 M, 4.19 × 10−9 M and 7.2 × 10−9 M, respectively, were obtained using differential pulse voltammetry. The developed sensor could detect two of the three (ibuprofen and indomethacin) simultaneously at significantly different potentials and exhibited remarkable reproducibility after a regeneration step. |
| first_indexed | 2024-12-13T05:43:17Z |
| format | Article |
| id | doaj.art-99dabbc2383f44e383f4830818603e9e |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-13T05:43:17Z |
| publishDate | 2020-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-99dabbc2383f44e383f4830818603e9e2022-12-21T23:57:44ZengElsevierArabian Journal of Chemistry1878-53522020-11-01131178097819Simultaneous non-steroidal anti-inflammatory drug electrodetection on nitrogen doped carbon nanodots and nanosized cobalt phthallocyanine conjugate modified glassy carbon electrodeNyaradzai Dondo0Munyaradzi Shumba1Mambo Moyo2Stephen Nyoni3Midlands State University, Department of Chemical Technology, P. Bag 9055, Senga Road, Gweru, ZimbabweMidlands State University, Department of Chemical Technology, P. Bag 9055, Senga Road, Gweru, ZimbabweMidlands State University, Department of Chemical Technology, P. Bag 9055, Senga Road, Gweru, ZimbabweChinhoyi University of Technology, Chemistry Department, P. Bag 7724, Chinhoyi, Zimbabwe; Corresponding author.Nitrogen doped carbon nanodots (NDCNDs) and nanosized cobalt tetra aminophenoxy phthalocyanines (CoTAPhPcNPs) modified glassy carbon electrodes have been successfully used in the simultaneous detection of aspirin (ASA), ibuprofen (IBU) and indomethacin (INDO). Scanning electron microscopy (SEM), transmission electron microscopy (TEM), UV–Vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were used to probe the nature of the synthesized nanomaterials. Sequential deposition of the nanomaterials on the glassy carbon electrode yielded CoTAPhPcNPs-NDCNDs-GCE with remarkable electrocatalytic performance. Electro-oxidation of the drugs at the electrode surface was first order. This work demonstrates the synergic effect of the two nanomaterials towards simultaneous electrocatalytic detection of the drugs. Superior detection limits of ASA, IBU and INDO being 9.66 × 10−9 M, 4.19 × 10−9 M and 7.2 × 10−9 M, respectively, were obtained using differential pulse voltammetry. The developed sensor could detect two of the three (ibuprofen and indomethacin) simultaneously at significantly different potentials and exhibited remarkable reproducibility after a regeneration step.http://www.sciencedirect.com/science/article/pii/S1878535220303361Nanosized cobalt tetra aminophenoxy phthalocyanineCarbon nanodotsNon-steroidal anti-inflammatory drugsElectro-detection |
| spellingShingle | Nyaradzai Dondo Munyaradzi Shumba Mambo Moyo Stephen Nyoni Simultaneous non-steroidal anti-inflammatory drug electrodetection on nitrogen doped carbon nanodots and nanosized cobalt phthallocyanine conjugate modified glassy carbon electrode Arabian Journal of Chemistry Nanosized cobalt tetra aminophenoxy phthalocyanine Carbon nanodots Non-steroidal anti-inflammatory drugs Electro-detection |
| title | Simultaneous non-steroidal anti-inflammatory drug electrodetection on nitrogen doped carbon nanodots and nanosized cobalt phthallocyanine conjugate modified glassy carbon electrode |
| title_full | Simultaneous non-steroidal anti-inflammatory drug electrodetection on nitrogen doped carbon nanodots and nanosized cobalt phthallocyanine conjugate modified glassy carbon electrode |
| title_fullStr | Simultaneous non-steroidal anti-inflammatory drug electrodetection on nitrogen doped carbon nanodots and nanosized cobalt phthallocyanine conjugate modified glassy carbon electrode |
| title_full_unstemmed | Simultaneous non-steroidal anti-inflammatory drug electrodetection on nitrogen doped carbon nanodots and nanosized cobalt phthallocyanine conjugate modified glassy carbon electrode |
| title_short | Simultaneous non-steroidal anti-inflammatory drug electrodetection on nitrogen doped carbon nanodots and nanosized cobalt phthallocyanine conjugate modified glassy carbon electrode |
| title_sort | simultaneous non steroidal anti inflammatory drug electrodetection on nitrogen doped carbon nanodots and nanosized cobalt phthallocyanine conjugate modified glassy carbon electrode |
| topic | Nanosized cobalt tetra aminophenoxy phthalocyanine Carbon nanodots Non-steroidal anti-inflammatory drugs Electro-detection |
| url | http://www.sciencedirect.com/science/article/pii/S1878535220303361 |
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