Intralymphatic GAD-alum Injection Modulates B Cell Response and Induces Follicular Helper T Cells and PD-1+ CD8+ T Cells in Patients With Recent-Onset Type 1 Diabetes

Intralymphatic GAD-alum Injection Modulates B Cell Response and Induces Follicular Helper T Cells and PD-1+ CD8+ T Cells in Patients With Recent-Onset Type 1 Diabetes

Antigen-specific immunotherapy is an appealing strategy to preserve beta-cell function in type 1 diabetes, although the approach has yet to meet its therapeutic endpoint. Direct administration of autoantigen into lymph nodes has emerged as an alternative administration route that can improve the eff...

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Bibliographic Details
Main Authors: Hugo Barcenilla, Mikael Pihl, Jeanette Wahlberg, Johnny Ludvigsson, Rosaura Casas
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
antigen-specific immunotherapy
type 1 diabetes
GAD-alum
mass cytometry (CyTOF)
follicular T helper cells
T cell exhaustion
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.797172/full

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