Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges
Exosomes are small intracellular membrane-based vesicles with different compositions that are involved in several biological and pathological processes. The exploitation of exosomes as drug delivery vehicles offers important advantages compared to other nanoparticulate drug delivery systems such as...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-07-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383515301003 |
| _version_ | 1818322373370183680 |
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| author | Dinh Ha Ningning Yang Venkatareddy Nadithe |
| author_facet | Dinh Ha Ningning Yang Venkatareddy Nadithe |
| author_sort | Dinh Ha |
| collection | DOAJ |
| description | Exosomes are small intracellular membrane-based vesicles with different compositions that are involved in several biological and pathological processes. The exploitation of exosomes as drug delivery vehicles offers important advantages compared to other nanoparticulate drug delivery systems such as liposomes and polymeric nanoparticles; exosomes are non-immunogenic in nature due to similar composition as body׳s own cells. In this article, the origin and structure of exosomes as well as their biological functions are outlined. We will then focus on specific applications of exosomes as drug delivery systems in pharmaceutical drug development. An overview of the advantages and challenges faced when using exosomes as a pharmaceutical drug delivery vehicles will also be discussed. |
| first_indexed | 2024-12-13T10:55:46Z |
| format | Article |
| id | doaj.art-99dd88dfb794461fa29804633c90d944 |
| institution | Directory Open Access Journal |
| issn | 2211-3835 2211-3843 |
| language | English |
| last_indexed | 2024-12-13T10:55:46Z |
| publishDate | 2016-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-99dd88dfb794461fa29804633c90d9442022-12-21T23:49:35ZengElsevierActa Pharmaceutica Sinica B2211-38352211-38432016-07-016428729610.1016/j.apsb.2016.02.001Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challengesDinh HaNingning YangVenkatareddy NaditheExosomes are small intracellular membrane-based vesicles with different compositions that are involved in several biological and pathological processes. The exploitation of exosomes as drug delivery vehicles offers important advantages compared to other nanoparticulate drug delivery systems such as liposomes and polymeric nanoparticles; exosomes are non-immunogenic in nature due to similar composition as body׳s own cells. In this article, the origin and structure of exosomes as well as their biological functions are outlined. We will then focus on specific applications of exosomes as drug delivery systems in pharmaceutical drug development. An overview of the advantages and challenges faced when using exosomes as a pharmaceutical drug delivery vehicles will also be discussed.http://www.sciencedirect.com/science/article/pii/S2211383515301003ExosomesNanocarrierExtracellular vesiclesDrug delivery systems |
| spellingShingle | Dinh Ha Ningning Yang Venkatareddy Nadithe Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges Acta Pharmaceutica Sinica B Exosomes Nanocarrier Extracellular vesicles Drug delivery systems |
| title | Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges |
| title_full | Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges |
| title_fullStr | Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges |
| title_full_unstemmed | Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges |
| title_short | Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges |
| title_sort | exosomes as therapeutic drug carriers and delivery vehicles across biological membranes current perspectives and future challenges |
| topic | Exosomes Nanocarrier Extracellular vesicles Drug delivery systems |
| url | http://www.sciencedirect.com/science/article/pii/S2211383515301003 |
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