Inhibition of DNA Repair in Combination with Temozolomide or Dianhydrogalactiol Overcomes Temozolomide-Resistant Glioma Cells

Inhibition of DNA Repair in Combination with Temozolomide or Dianhydrogalactiol Overcomes Temozolomide-Resistant Glioma Cells

Resistance to temozolomide and intratumoral heterogeneity contribute to the poor prognosis of glioma. The mechanisms of temozolomide resistance can vary within a heterogeneous tumor. Temozolomide adds a methyl group to DNA. The primary cytotoxic lesion, O6-methylguanine, mispairs with thymine, leadi...

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Bibliographic Details
Main Authors: Shigeo Ohba, Kei Yamashiro, Yuichi Hirose
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
dianhydrogalactiol
drug resistance
glioma
PAPR inhibitor
temozolomide
Online Access:https://www.mdpi.com/2072-6694/13/11/2570

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