A Cell-Penetrating Peptide Improves Anti-HER2 Single-Chain Variable Fragment Internalization and Antitumor Activity against HER2-Positive Breast Cancer In Vitro and In Vivo

A Cell-Penetrating Peptide Improves Anti-HER2 Single-Chain Variable Fragment Internalization and Antitumor Activity against HER2-Positive Breast Cancer In Vitro and In Vivo

Cell-penetrating peptides (CPPs) are invaluable tools for delivering various substances into cells by crossing biological membranes. However, the effects of cell-penetrating peptide fusion proteins on the biological activity of antibodies remain to be fully understood. Here, we engineered a recombin...

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Bibliographic Details
Main Authors: Junmin Li, Yanting Zhou, Zhuowei Su, Xue Li, Lei Zhang, Shan Li
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Molecules
Subjects:
HER2-positive breast cancer
scFv
leader peptide-scFv
internalization
antitumor activity
Online Access:https://www.mdpi.com/1420-3049/29/6/1247

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