Antihyperlipidemic and Hepatoprotective Activity of Dodonaea viscosa Leaves Extracts in Alloxan-Induced Diabetic Rabbits (Oryctolagus cuniculus)
Hyperlipidemia is associated with diabetes and hepatotoxicity has emerged as a common clinical complication by antidiabetics. The present study was conducted to determine the antihyperlipidemic and hepatoprotective activity of Dodonaea viscosa leaves extracts in the alloxan-induced diabetic rabbits....
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| Format: | Article |
| Language: | English |
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University of Agriculture, Faisalabad
2012-01-01
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| Series: | Pakistan Veterinary Journal |
| Subjects: | |
| Online Access: | http://pvj.com.pk/pdf-files/32_1/50-54.pdf |
| _version_ | 1831688176813473792 |
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| author | Maqsood Ahmad, Qaisar Mahmood, Kamran Gulzar1, Muhammad Shoaib Akhtar1, Mohammad Saleem and Muhammad Imran Qadir* |
| author_facet | Maqsood Ahmad, Qaisar Mahmood, Kamran Gulzar1, Muhammad Shoaib Akhtar1, Mohammad Saleem and Muhammad Imran Qadir* |
| author_sort | Maqsood Ahmad, Qaisar Mahmood, Kamran Gulzar1, Muhammad Shoaib Akhtar1, Mohammad Saleem and Muhammad Imran Qadir* |
| collection | DOAJ |
| description | Hyperlipidemia is associated with diabetes and hepatotoxicity has emerged as a common clinical complication by antidiabetics. The present study was conducted to determine the antihyperlipidemic and hepatoprotective activity of Dodonaea viscosa leaves extracts in the alloxan-induced diabetic rabbits. The rabbits (n = 70) were divided into seven groups including normal and diabetic control, the remaining were aqueous, aqueous:methanol (70:30), aqueous:methanol (50:50), aqueous: methanol (30:70), and methanol extracts given for 30 days. Serum levels of triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, ALT and AST were estimated by using commercially available kits. The oral administration of aqueous:methanol (70:30) extract of the Dodonaea viscosa leaves significantly (P<0.01) decreased the raised parameters (triglyceride, total cholesterol and LDL-cholesterol) to normal values. But the extract has significantly increased HDL-cholesterol, ALT and AST levels. For the aqueous:methanol (70:30) extract given animals, the average serum level of total cholesterol was 60.00±1.30 mg/dL, LDL-cholesterol was 92.80±2.29 mg/dL, HDL-cholesterol was 31.80±1.0 mg/dL and triglyceride was 15.40±0.75 mg/dL while the average serum levels of ALT and AST were 45.60±3.08 and 27.20±1.36 IU/dL, respectively. It is concluded from the study that aqueous:methanolic (70:30) extract of Dodonaea viscosa leaves exerts antihy- perlipidemic and hepatoprotective effects in the alloxan-induced diabetic rabbits. |
| first_indexed | 2024-12-20T09:11:55Z |
| format | Article |
| id | doaj.art-99e2a1103f19476397ce694466f20a55 |
| institution | Directory Open Access Journal |
| issn | 0253-8318 |
| language | English |
| last_indexed | 2024-12-20T09:11:55Z |
| publishDate | 2012-01-01 |
| publisher | University of Agriculture, Faisalabad |
| record_format | Article |
| series | Pakistan Veterinary Journal |
| spelling | doaj.art-99e2a1103f19476397ce694466f20a552022-12-21T19:45:32ZengUniversity of Agriculture, FaisalabadPakistan Veterinary Journal0253-83182012-01-013215054Antihyperlipidemic and Hepatoprotective Activity of Dodonaea viscosa Leaves Extracts in Alloxan-Induced Diabetic Rabbits (Oryctolagus cuniculus)Maqsood Ahmad, Qaisar Mahmood, Kamran Gulzar1, Muhammad Shoaib Akhtar1, Mohammad Saleem and Muhammad Imran Qadir*Hyperlipidemia is associated with diabetes and hepatotoxicity has emerged as a common clinical complication by antidiabetics. The present study was conducted to determine the antihyperlipidemic and hepatoprotective activity of Dodonaea viscosa leaves extracts in the alloxan-induced diabetic rabbits. The rabbits (n = 70) were divided into seven groups including normal and diabetic control, the remaining were aqueous, aqueous:methanol (70:30), aqueous:methanol (50:50), aqueous: methanol (30:70), and methanol extracts given for 30 days. Serum levels of triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, ALT and AST were estimated by using commercially available kits. The oral administration of aqueous:methanol (70:30) extract of the Dodonaea viscosa leaves significantly (P<0.01) decreased the raised parameters (triglyceride, total cholesterol and LDL-cholesterol) to normal values. But the extract has significantly increased HDL-cholesterol, ALT and AST levels. For the aqueous:methanol (70:30) extract given animals, the average serum level of total cholesterol was 60.00±1.30 mg/dL, LDL-cholesterol was 92.80±2.29 mg/dL, HDL-cholesterol was 31.80±1.0 mg/dL and triglyceride was 15.40±0.75 mg/dL while the average serum levels of ALT and AST were 45.60±3.08 and 27.20±1.36 IU/dL, respectively. It is concluded from the study that aqueous:methanolic (70:30) extract of Dodonaea viscosa leaves exerts antihy- perlipidemic and hepatoprotective effects in the alloxan-induced diabetic rabbits.http://pvj.com.pk/pdf-files/32_1/50-54.pdfALTAntihyperlipidaemicASTDodonaea viscoseHDL-cholesterolHepatoprotectiveLDL-cholesterolRabbitsTotal cholesterolTriglyceride |
| spellingShingle | Maqsood Ahmad, Qaisar Mahmood, Kamran Gulzar1, Muhammad Shoaib Akhtar1, Mohammad Saleem and Muhammad Imran Qadir* Antihyperlipidemic and Hepatoprotective Activity of Dodonaea viscosa Leaves Extracts in Alloxan-Induced Diabetic Rabbits (Oryctolagus cuniculus) Pakistan Veterinary Journal ALT Antihyperlipidaemic AST Dodonaea viscose HDL-cholesterol Hepatoprotective LDL-cholesterol Rabbits Total cholesterol Triglyceride |
| title | Antihyperlipidemic and Hepatoprotective Activity of Dodonaea viscosa Leaves Extracts in Alloxan-Induced Diabetic Rabbits (Oryctolagus cuniculus) |
| title_full | Antihyperlipidemic and Hepatoprotective Activity of Dodonaea viscosa Leaves Extracts in Alloxan-Induced Diabetic Rabbits (Oryctolagus cuniculus) |
| title_fullStr | Antihyperlipidemic and Hepatoprotective Activity of Dodonaea viscosa Leaves Extracts in Alloxan-Induced Diabetic Rabbits (Oryctolagus cuniculus) |
| title_full_unstemmed | Antihyperlipidemic and Hepatoprotective Activity of Dodonaea viscosa Leaves Extracts in Alloxan-Induced Diabetic Rabbits (Oryctolagus cuniculus) |
| title_short | Antihyperlipidemic and Hepatoprotective Activity of Dodonaea viscosa Leaves Extracts in Alloxan-Induced Diabetic Rabbits (Oryctolagus cuniculus) |
| title_sort | antihyperlipidemic and hepatoprotective activity of dodonaea viscosa leaves extracts in alloxan induced diabetic rabbits oryctolagus cuniculus |
| topic | ALT Antihyperlipidaemic AST Dodonaea viscose HDL-cholesterol Hepatoprotective LDL-cholesterol Rabbits Total cholesterol Triglyceride |
| url | http://pvj.com.pk/pdf-files/32_1/50-54.pdf |
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