Spine and sacroiliac joints on magnetic resonance imaging in patients with early axial spondyloarthritis: prevalence of lesions and association with clinical and disease activity indices from the Italian group of the SPACE study
Our aim was to determine the prevalence of spine and sacroiliac joint (SIJ) lesions on magnetic resonance imaging (MRI) in patients with early axial spondyloarthritis (axSpA) and their correlation with disease activity indices. Sixty patients with low back pain (LBP) (≥3 months, ≤2 years, onset ≤45...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2016-09-01
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| Series: | Reumatismo |
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| Online Access: | http://www.reumatismo.org/index.php/reuma/article/view/885 |
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| author | M. Lorenzin A. Ortolan P. Frallonardo S. Vio C. Lacognata F. Oliviero L. Punzi R. Ramonda |
| author_facet | M. Lorenzin A. Ortolan P. Frallonardo S. Vio C. Lacognata F. Oliviero L. Punzi R. Ramonda |
| author_sort | M. Lorenzin |
| collection | DOAJ |
| description | Our aim was to determine the prevalence of spine and sacroiliac joint (SIJ) lesions on magnetic resonance imaging (MRI) in patients with early axial spondyloarthritis (axSpA) and their correlation with disease activity indices. Sixty patients with low back pain (LBP) (≥3 months, ≤2 years, onset ≤45 years), attending the SpA-clinic of the Unità Operativa Complessa Reumatologia of Padova [SpondyloArthritis-Caught-Early (SPACE) study], were studied following a protocol including physical examination, questionnaires, laboratory tests, X-rays and spine and SIJ MRI. Positive spine and SIJ MRI and X-rays images were scored independently by 2 readers using the SPARCC method, modified Stoke ankylosing spondylitis spine score and New York criteria. The axial pain and localization of MRI-lesions were referred to 4 sites: cervical/thoracic/lumbar spine and SIJ. All patients were classified into three groups: patients with signs of radiographic sacroiliitis (r-axSpA), patients without signs of r-axSpA but with signs of sacroiliitis on MRI (nr-axSpA MRI SIJ+), patients without signs of sacroiliitis on MRI and X-rays (nr-axSpA MRI SIJ-). The median age at LBP onset was 29.05±8.38 years; 51.6% of patients showed bone marrow edema (BME) in spine-MRI and 56.7% of patients in SIJ-MRI. Signs of enthesitis were found in 55% of patients in the thoracic district. Of the 55% of patients with BME on spine-MRI, 15% presented presented a negative SIJMRI. There was a significant difference between these cohorts with regard to the prevalence of radiographic sacroiliitis, active sacroiliitis on MRI and SPARCC SIJ score. The site of pain correlated statistically with BME lesions in thoracic and buttock districts. Since positive spine-MRI images were observed in absence of sacroiliitis, we can hypothesize that this finding could have a diagnostic significance in axSpA suspected axSpA. |
| first_indexed | 2024-04-13T04:44:24Z |
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| issn | 0048-7449 2240-2683 |
| language | English |
| last_indexed | 2024-04-13T04:44:24Z |
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| spelling | doaj.art-99e3a34c308f4e1eb289b0c64baef5392022-12-22T03:01:53ZengPAGEPress PublicationsReumatismo0048-74492240-26832016-09-01682728210.4081/reumatismo.2016.885714Spine and sacroiliac joints on magnetic resonance imaging in patients with early axial spondyloarthritis: prevalence of lesions and association with clinical and disease activity indices from the Italian group of the SPACE studyM. Lorenzin0A. Ortolan1P. Frallonardo2S. Vio3C. Lacognata4F. Oliviero5L. Punzi6R. Ramonda7Rheumatology Unit, Department of Medicine, University of PadovaRheumatology Unit, Department of Medicine, University of PadovaRheumatology Unit, Department of Medicine, University of PadovaRadiology Unit, University of PadovaRadiology Unit, University of PadovaRheumatology Unit, Department of Medicine, University of PadovaRheumatology Unit, Department of Medicine, University of PadovaRheumatology Unit, Department of Medicine, University of PadovaOur aim was to determine the prevalence of spine and sacroiliac joint (SIJ) lesions on magnetic resonance imaging (MRI) in patients with early axial spondyloarthritis (axSpA) and their correlation with disease activity indices. Sixty patients with low back pain (LBP) (≥3 months, ≤2 years, onset ≤45 years), attending the SpA-clinic of the Unità Operativa Complessa Reumatologia of Padova [SpondyloArthritis-Caught-Early (SPACE) study], were studied following a protocol including physical examination, questionnaires, laboratory tests, X-rays and spine and SIJ MRI. Positive spine and SIJ MRI and X-rays images were scored independently by 2 readers using the SPARCC method, modified Stoke ankylosing spondylitis spine score and New York criteria. The axial pain and localization of MRI-lesions were referred to 4 sites: cervical/thoracic/lumbar spine and SIJ. All patients were classified into three groups: patients with signs of radiographic sacroiliitis (r-axSpA), patients without signs of r-axSpA but with signs of sacroiliitis on MRI (nr-axSpA MRI SIJ+), patients without signs of sacroiliitis on MRI and X-rays (nr-axSpA MRI SIJ-). The median age at LBP onset was 29.05±8.38 years; 51.6% of patients showed bone marrow edema (BME) in spine-MRI and 56.7% of patients in SIJ-MRI. Signs of enthesitis were found in 55% of patients in the thoracic district. Of the 55% of patients with BME on spine-MRI, 15% presented presented a negative SIJMRI. There was a significant difference between these cohorts with regard to the prevalence of radiographic sacroiliitis, active sacroiliitis on MRI and SPARCC SIJ score. The site of pain correlated statistically with BME lesions in thoracic and buttock districts. Since positive spine-MRI images were observed in absence of sacroiliitis, we can hypothesize that this finding could have a diagnostic significance in axSpA suspected axSpA.http://www.reumatismo.org/index.php/reuma/article/view/885Axial spondyloarthritisearly onset spondyloarthritisdisease activityclinimetric indices spinesacroiliac joints. |
| spellingShingle | M. Lorenzin A. Ortolan P. Frallonardo S. Vio C. Lacognata F. Oliviero L. Punzi R. Ramonda Spine and sacroiliac joints on magnetic resonance imaging in patients with early axial spondyloarthritis: prevalence of lesions and association with clinical and disease activity indices from the Italian group of the SPACE study Reumatismo Axial spondyloarthritis early onset spondyloarthritis disease activity clinimetric indices spine sacroiliac joints. |
| title | Spine and sacroiliac joints on magnetic resonance imaging in patients with early axial spondyloarthritis: prevalence of lesions and association with clinical and disease activity indices from the Italian group of the SPACE study |
| title_full | Spine and sacroiliac joints on magnetic resonance imaging in patients with early axial spondyloarthritis: prevalence of lesions and association with clinical and disease activity indices from the Italian group of the SPACE study |
| title_fullStr | Spine and sacroiliac joints on magnetic resonance imaging in patients with early axial spondyloarthritis: prevalence of lesions and association with clinical and disease activity indices from the Italian group of the SPACE study |
| title_full_unstemmed | Spine and sacroiliac joints on magnetic resonance imaging in patients with early axial spondyloarthritis: prevalence of lesions and association with clinical and disease activity indices from the Italian group of the SPACE study |
| title_short | Spine and sacroiliac joints on magnetic resonance imaging in patients with early axial spondyloarthritis: prevalence of lesions and association with clinical and disease activity indices from the Italian group of the SPACE study |
| title_sort | spine and sacroiliac joints on magnetic resonance imaging in patients with early axial spondyloarthritis prevalence of lesions and association with clinical and disease activity indices from the italian group of the space study |
| topic | Axial spondyloarthritis early onset spondyloarthritis disease activity clinimetric indices spine sacroiliac joints. |
| url | http://www.reumatismo.org/index.php/reuma/article/view/885 |
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