| Summary: | Surfactants are extensively utilized and have become a necessity in our daily lives. On the other hand, increasing surfactant production has raised global warming and environmental issues, necessitating finding new sustainable alternatives. Carbohydrate-based surfactants derived from renewable sources are good candidates for solving this issue. In the last decade, the development of this class was extensively studied. However, the cationic branch has been the least investigated, which is unfortunate because they are environmentally friendly, biocompatible, and biodegradable materials that can be used to treat microbes and dermatologic diseases compared to other surfactants. These features are useful for a variety of applications, including antiseptics and gene delivery. Consequently, developing alternative, sustainable procedures to produce carbohydrate-based surfactants is crucial. This review has compiled and described the present synthetic methodologies for producing carbohydrate cationic-based surfactants.
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