PSIP1/LEDGF reduces R-loops at transcription sites to maintain genome integrity

PSIP1/LEDGF reduces R-loops at transcription sites to maintain genome integrity

Abstract R-loops that accumulate at transcription sites pose a persistent threat to genome integrity. PSIP1 is a chromatin protein associated with transcriptional elongation complex, possesses histone chaperone activity, and is implicated in recruiting RNA processing and DNA repair factors to transc...

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Bibliographic Details
Main Authors: Sundarraj Jayakumar, Manthan Patel, Fanny Boulet, Hadicha Aziz, Greg N. Brooke, Hemanth Tummala, Madapura M. Pradeepa
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-44544-w

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