Correlation of compliance to statin therapy with lipid profile and serum HMGCoA reductase levels in dyslipidemic patients
Background: The efficacy of statin therapy may be lost or vary with reduction in compliance and intensity of statin therapy. Objective: To study and correlate the quantitative effect of compliance on lipid profile and 3-hydroxyl-3-methylglutaryl coenzyme A reductase (HMGCoA-R) levels in dyslipidemic...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-01-01
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| Series: | Indian Heart Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0019483216302620 |
| _version_ | 1819283054181482496 |
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| author | Abhinav Grover Harmeet Singh Rehan Lalit Kumar Gupta Madhur Yadav |
| author_facet | Abhinav Grover Harmeet Singh Rehan Lalit Kumar Gupta Madhur Yadav |
| author_sort | Abhinav Grover |
| collection | DOAJ |
| description | Background: The efficacy of statin therapy may be lost or vary with reduction in compliance and intensity of statin therapy.
Objective: To study and correlate the quantitative effect of compliance on lipid profile and 3-hydroxyl-3-methylglutaryl coenzyme A reductase (HMGCoA-R) levels in dyslipidemic patients.
Methods: Compliance to different intensity of statin therapy assessed by pill count was correlated with serum levels of total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), triglycerides (TG), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB) and HMGCoA-R.
Results: Out of 200 patients, 160 received moderate intensity statin therapy whereas 40 were on high intensity statin therapy. The overall mean compliance of patients was 56.7%. The compliance of patients on moderate intensity statin therapy was higher (56.8%) than those on high intensity (56.4%) (p = 0.92). There was significant inverse correlation (p < 0.05) between compliance and TC, TG, LDL-C and HMGCoA-R levels and positive correlation (p < 0.05) with HDL-C levels. The mean serum HMGCoA-R levels did not fall below 9–10 ng/mL when compliance to either moderate or high intensity statin therapy was increased above 60%.
Conclusions: It is appropriate to improve the compliance to existing statin therapy than switching over to higher intensity statin therapy. Estimation of HMGCoA-R levels may be explored as a surrogate marker to monitor and assess the compliance of patients to statin therapy. |
| first_indexed | 2024-12-24T01:25:23Z |
| format | Article |
| id | doaj.art-99eb7880579b452292bd3013e575ac13 |
| institution | Directory Open Access Journal |
| issn | 0019-4832 |
| language | English |
| last_indexed | 2024-12-24T01:25:23Z |
| publishDate | 2017-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Indian Heart Journal |
| spelling | doaj.art-99eb7880579b452292bd3013e575ac132022-12-21T17:22:30ZengElsevierIndian Heart Journal0019-48322017-01-0169161010.1016/j.ihj.2016.07.007Correlation of compliance to statin therapy with lipid profile and serum HMGCoA reductase levels in dyslipidemic patientsAbhinav Grover0Harmeet Singh Rehan1Lalit Kumar Gupta2Madhur Yadav3Department of Pharmacology, Lady Hardinge Medical College and Associated Hospitals, New Delhi, IndiaDepartment of Medicine, Lady Hardinge Medical College and Associated Hospitals, New Delhi, IndiaDepartment of Pharmacology, Lady Hardinge Medical College and Associated Hospitals, New Delhi, IndiaDepartment of Pharmacology, Lady Hardinge Medical College and Associated Hospitals, New Delhi, IndiaBackground: The efficacy of statin therapy may be lost or vary with reduction in compliance and intensity of statin therapy. Objective: To study and correlate the quantitative effect of compliance on lipid profile and 3-hydroxyl-3-methylglutaryl coenzyme A reductase (HMGCoA-R) levels in dyslipidemic patients. Methods: Compliance to different intensity of statin therapy assessed by pill count was correlated with serum levels of total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), triglycerides (TG), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB) and HMGCoA-R. Results: Out of 200 patients, 160 received moderate intensity statin therapy whereas 40 were on high intensity statin therapy. The overall mean compliance of patients was 56.7%. The compliance of patients on moderate intensity statin therapy was higher (56.8%) than those on high intensity (56.4%) (p = 0.92). There was significant inverse correlation (p < 0.05) between compliance and TC, TG, LDL-C and HMGCoA-R levels and positive correlation (p < 0.05) with HDL-C levels. The mean serum HMGCoA-R levels did not fall below 9–10 ng/mL when compliance to either moderate or high intensity statin therapy was increased above 60%. Conclusions: It is appropriate to improve the compliance to existing statin therapy than switching over to higher intensity statin therapy. Estimation of HMGCoA-R levels may be explored as a surrogate marker to monitor and assess the compliance of patients to statin therapy.http://www.sciencedirect.com/science/article/pii/S0019483216302620DyslipidemiaComplianceHMGCoA reductaseAtorvastatinRosuvastatin |
| spellingShingle | Abhinav Grover Harmeet Singh Rehan Lalit Kumar Gupta Madhur Yadav Correlation of compliance to statin therapy with lipid profile and serum HMGCoA reductase levels in dyslipidemic patients Indian Heart Journal Dyslipidemia Compliance HMGCoA reductase Atorvastatin Rosuvastatin |
| title | Correlation of compliance to statin therapy with lipid profile and serum HMGCoA reductase levels in dyslipidemic patients |
| title_full | Correlation of compliance to statin therapy with lipid profile and serum HMGCoA reductase levels in dyslipidemic patients |
| title_fullStr | Correlation of compliance to statin therapy with lipid profile and serum HMGCoA reductase levels in dyslipidemic patients |
| title_full_unstemmed | Correlation of compliance to statin therapy with lipid profile and serum HMGCoA reductase levels in dyslipidemic patients |
| title_short | Correlation of compliance to statin therapy with lipid profile and serum HMGCoA reductase levels in dyslipidemic patients |
| title_sort | correlation of compliance to statin therapy with lipid profile and serum hmgcoa reductase levels in dyslipidemic patients |
| topic | Dyslipidemia Compliance HMGCoA reductase Atorvastatin Rosuvastatin |
| url | http://www.sciencedirect.com/science/article/pii/S0019483216302620 |
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