Role of Antifungal Combinations in Difficult to Treat <i>Candida</i> Infections
<i>Candida</i> infections are varied and, depending on the immune status of the patient, a life-threatening form may develop. <i>C. albicans</i> is the most prevalent species isolated, however, a significant shift towards other <i>Candida</i> species has been note...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Journal of Fungi |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2309-608X/7/9/731 |
| _version_ | 1797518605805420544 |
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| author | Roxana G. Vitale |
| author_facet | Roxana G. Vitale |
| author_sort | Roxana G. Vitale |
| collection | DOAJ |
| description | <i>Candida</i> infections are varied and, depending on the immune status of the patient, a life-threatening form may develop. <i>C. albicans</i> is the most prevalent species isolated, however, a significant shift towards other <i>Candida</i> species has been noted. Monotherapy is frequently indicated, but the patient’s evolution is not always favorable. Drug combinations are a suitable option in specific situations. The aim of this review is to address this problem and to discuss the role of drug combinations in difficult to treat <i>Candida</i> infections. A search for eligible studies in PubMed and Google Scholar databases was performed. An analysis of the data was carried out to define in which cases a combination therapy is the most appropriate. Combination therapy may be used for refractory candidiasis, endocarditis, meningitis, eye infections and osteomyelitis, among others. The role of the drug combination would be to increase efficacy, reduce toxicity and improve the prognosis of the patient in infections that are difficult to treat. More clinical studies and reporting of cases in which drug combinations are used are needed in order to have more data that support the use of this therapeutic strategy. |
| first_indexed | 2024-03-10T07:32:06Z |
| format | Article |
| id | doaj.art-99ed11a6aea041fca28e1822e4e46a32 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T07:32:06Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-99ed11a6aea041fca28e1822e4e46a322023-11-22T13:48:07ZengMDPI AGJournal of Fungi2309-608X2021-09-017973110.3390/jof7090731Role of Antifungal Combinations in Difficult to Treat <i>Candida</i> InfectionsRoxana G. Vitale0Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Buenos Aires, Argentina<i>Candida</i> infections are varied and, depending on the immune status of the patient, a life-threatening form may develop. <i>C. albicans</i> is the most prevalent species isolated, however, a significant shift towards other <i>Candida</i> species has been noted. Monotherapy is frequently indicated, but the patient’s evolution is not always favorable. Drug combinations are a suitable option in specific situations. The aim of this review is to address this problem and to discuss the role of drug combinations in difficult to treat <i>Candida</i> infections. A search for eligible studies in PubMed and Google Scholar databases was performed. An analysis of the data was carried out to define in which cases a combination therapy is the most appropriate. Combination therapy may be used for refractory candidiasis, endocarditis, meningitis, eye infections and osteomyelitis, among others. The role of the drug combination would be to increase efficacy, reduce toxicity and improve the prognosis of the patient in infections that are difficult to treat. More clinical studies and reporting of cases in which drug combinations are used are needed in order to have more data that support the use of this therapeutic strategy.https://www.mdpi.com/2309-608X/7/9/731<i>Candida</i> infectionsantifungal combinationsmanagementamphotericin Bazolesechinocandins |
| spellingShingle | Roxana G. Vitale Role of Antifungal Combinations in Difficult to Treat <i>Candida</i> Infections Journal of Fungi <i>Candida</i> infections antifungal combinations management amphotericin B azoles echinocandins |
| title | Role of Antifungal Combinations in Difficult to Treat <i>Candida</i> Infections |
| title_full | Role of Antifungal Combinations in Difficult to Treat <i>Candida</i> Infections |
| title_fullStr | Role of Antifungal Combinations in Difficult to Treat <i>Candida</i> Infections |
| title_full_unstemmed | Role of Antifungal Combinations in Difficult to Treat <i>Candida</i> Infections |
| title_short | Role of Antifungal Combinations in Difficult to Treat <i>Candida</i> Infections |
| title_sort | role of antifungal combinations in difficult to treat i candida i infections |
| topic | <i>Candida</i> infections antifungal combinations management amphotericin B azoles echinocandins |
| url | https://www.mdpi.com/2309-608X/7/9/731 |
| work_keys_str_mv | AT roxanagvitale roleofantifungalcombinationsindifficulttotreaticandidaiinfections |