Genome-Wide Off-Target Analysis in CRISPR-Cas9 Modified Mice and Their Offspring

Genome-Wide Off-Target Analysis in CRISPR-Cas9 Modified Mice and Their Offspring

The emergence of the CRISPR-Cas9 system has triggered a technical revolution in mammalian genome editing. Compared to traditional gene-targeting strategies, CRISPR-Cas9 technology offers a more efficient and cost-effective approach for generating genetically modified animal models. However, off-targ...

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Bibliographic Details
Main Authors: Yan Dong, Haimei Li, Liang Zhao, Peter Koopman, Feng Zhang, Johnny X. Huang
Format: Article
Language:English
Published: Oxford University Press 2019-11-01
Series:G3: Genes, Genomes, Genetics
Subjects:
crispr-cas9
off-target
whole-genome sequencing
genome editing
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.119.400503

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